29201-97-6

Upstream product

• 938041-78-2 4'-benzyloxy-3',5,6,7,8-pentamethoxyflavanone 
• 2426-87-1 3-methoxy-4-(phenylmethoxy)benzaldehyde 
• 41318-10-9 2-hydroxy-3,4,6-trimethoxyacetophenone 
• 56002-81-4 1,2-dihydroxy-3,4,6-trimethoxybenzene 
• 13909-75-6 1,2,3,4,5-pentamethoxybenzene 
• 29201-96-5 C₂₇H₂₈O₉ 
• 14786-40-4 1-(2,3,4,5,6-pentamethoxyphenyl)ethan-1-one 
• 91556-09-1 2,3,4,5,6-pentamethoxybenzoic acid 
• 92157-76-1 methyl 2,3,4,5,6-pentamethoxybenzoate 
• 7169-08-6 2,3,4,5,6-Pentamethoxy-benzoylchlorid 
• 34810-60-1 2-(3-Methoxy-4-benzyloxy-benzoyloxy)-3,4,5,6-tetramethoxyacetophenon 
• 100-39-0 benzyl bromide 
• 1228255-36-4 (1H-benzo[d][1,2,3]triazol-1-yl)(4-(benzyloxy)-3-methoxyphenyl)methanone 
• 121-34-6 3-methoxy-4-hydroxybenzoic acid 

Downstream Products

• 34810-62-3 3′-methoxy-4′-hydroxy-5,6,7,8-tetramethoxyflavone 
• 16520-78-8 8-methoxycirsilineol 
• 1350827-34-7 4'-benzyloxy-5-hydroxy-3',6,7,8-tetramethoxyflavone 

Relevant academic research and scientific papers

Practical Synthesis of Polymethylated Flavones: Nobiletin and Its Desmethyl Derivatives

We present a practical synthesis of the polymethoxylated citrus flavone nobiletin that is suitable for use on a hundred gram scale. Ready availability of this compound and its derivatives will aid detailed chemical-biological investigations of their biological activities, including activation of signaling via the cAMP-dependent protein kinase A/extracellular signal-related protein kinase/cAMP response element-binding protein pathway.

Concise synthesis of polymethoxyflavone sudachitin and its derivatives, and biological evaluations

We accomplished a divergent synthesis of sudachitin (2), a polymethoxyflavone isolated from citrus fruits, and six derivatives from acetophenone 9, which was an intermediate in our previous synthesis of nobiletin (1). Compound 2 enhanced glucose-induced i

Nobiletin metabolites: Synthesis and inhibitory activity against matrix metalloproteinase-9 production

A divergent synthesis of nobiletin metabolites was developed through highly oxygenated acetophenone derivative. We used commercially available methyl 3,4,5-trimethoxybenzoate as a starting material for concise preparation of the key intermediate, 2′-hydro

COGNITIVE DISORDER-AMELIORATING AGENT

A cognitive impairment ameliorant is provided that is useful for the prevention or treatment of cognitive impairment, and particularly Alzheimer's disease. The cognitive impairment ameliorant contains royal jelly as an active ingredient thereof.

Isolation and syntheses of polymethoxyflavones and hydroxylated polymethoxyflavones as inhibitors of HL-60 cell lines

Fifteen polymethoxyflavones (PMFs) and hydroxylated PMFs were isolated from sweet orange (Citrus sinensis) peel extract and synthesized to investigate their biological activity. All obtained compounds were tested in HL-60 cancer cell proliferation and apoptosis induction assays. While some PMFs and hydroxylated PMFs had moderate anti-carcinogenic activities, 5-hydroxy-6,7,8,3′,4′-pentamethoxyflavone and 5-hydroxy-3,6,7,8,3′,4′-hexamethoxyflavone showed strong inhibitory activities against the proliferation and induced apoptosis of HL-60 cell lines.