29202-80-0Relevant articles and documents
Enantioselective Synthesis of Tetrahydroquinolines via One-Pot Cascade Biomimetic Reduction?
Zhao, Zi-Biao,Li, Xiang,Chen, Mu-Wang,Wu, Bo,Zhou, Yong-Gui
supporting information, p. 1691 - 1695 (2020/11/03)
A novel and efficient protocol for the synthesis of chiral tetrahydroquinoline derivatives with excellent enantioselectivities and high yields has been developed through one-pot cascade biomimetic reduction. The detailed reaction pathway includes the acid-catalyzed and ruthenium-catalyzed formation of aromatic quinoline intermediates and biomimetic asymmetric reduction.
Containing nitro of curcumin derivatives and its preparation method and application
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Paragraph 0068; 0069; 0070, (2017/08/25)
The invention discloses a curcumin derivative as shown in formula (I) as well as a preparation method and application of the curcumin derivative. The invention provides a novel curcumin derivative, and the derivative has an anti-inflammatory activity and can be used as an active ingredient in anti-inflammatory drugs or anti-inflammatory pharmaceutical compositions. Furthermore, the invention also provides a preparation method of the curcumin derivative as shown in formula (I). The invention belongs to the technical field of chemical drugs; the curcumin derivative is better than curcumin in stability, and the curcumin derivative is low in preparation cost and good in realizability.
Blue-light-promoted carbon-carbon double bond isomerization and its application in the syntheses of quinolines
Chen, Xinzheng,Qiu, Shuxian,Wang, Sasa,Wang, Huifei,Zhai, Hongbin
supporting information, p. 6349 - 6352 (2017/08/10)
A blue-light-promoted carbon-carbon double bond isomerization in the absence of any photoredox catalyst is reported. It provides rapid access to a series of quinolines in good to excellent yields under simple aerobic conditions. The protocol is direct, catalyst-free and operationally convenient.
Application of Deep Eutectic Solvents in Promiscuous Lipase-Catalysed Aldol Reactions
González-Martínez, Daniel,Gotor, Vicente,Gotor-Fernández, Vicente
supporting information, p. 1513 - 1519 (2016/04/05)
The application of deep eutectic solvents has been demonstrated for the first time in promiscuous lipase-catalysed aldol reactions. The model reaction between 4-nitrobenzaldehyde and acetone was examined in depth, with excellent compatibility being found between porcine pancreas lipase and choline chloride/glycerol mixtures for the formation of the aldol product in high yields. The system was compatible with a series of aromatic aldehydes and ketones including acetone, cyclopentanone and cyclohexanone. In some cases, the corresponding α,β-unsaturated carbonyl compounds were found as minor products. Control experiments demonstrate that the enzymatic preparation was also responsible for a collateral dehydration reaction once the aldol product is formed. Deep eutectic solvents are used for the first time in promiscuous lipase-catalysed aldol reactions. The reaction between substituted benzaldehydes and aliphatic ketones has excellent compatibility with porcine pancreas lipase (PPL) and choline chloride/glycerol mixtures and gives the aldol product in high yields. PPL was also responsible for a collateral dehydration reaction.
Modified calcium oxide as stable solid base catalyst for Aldol condensation reaction
Tang, Ying,Xu, Jingfang,Gu, Xuefan
, p. 313 - 320 (2013/07/26)
A highly efficient and stable solid-base catalyst for Aldol condensation was prepared by modifying commercial CaO with benzyl bromide in a simple way. It was found that modified CaO can effectively catalyse the Aldol condensation of cyclohexanone and benzaldehyde, as well as various benzaldehydes, to produce 2-benzylidenecyclohexanone with a good selectivity and high yield. Higher yield of 95.8% was obtained over modified CaO after 3 h, which is short compared with the yield of 92.1% after 12 h over commercial CaO. The influence of several reaction parameters, such as temperature, catalyst loading, was investigated. The humidity test over modified CaO reveals that the basic centres of modified CaO are stable for CO2 and moisture. From the results of Fourier transform-infrared (FT-IR) and Thermogravity analysis (TG) characterization, the modifier was bonded on surface of CaO chemically and almost no Ca(OH) 2 formed during the modification process. The type of aldehyde has great influence on the yield of aldol condensation.
Asymmetrical 2,6-bis(benzylidene)cyclohexanones: Synthesis, cytotoxic activity and QSAR study
Nakhjiri, Maryam,Safavi, Maliheh,Alipour, Eskandar,Emami, Saeed,Atash, Amir Farzin,Jafari-Zavareh, Mona,Ardestani, Sussan K.,Khoshneviszadeh, Mehdi,Foroumadi, Alireza,Shafiee, Abbas
experimental part, p. 113 - 123 (2012/07/03)
In order to develop novel anti-cancer agents, a series of asymmetrical 2,6-bis (benzylidene)cyclohexanone derivatives containing nitrobenzylidene moiety were synthesized and their cytotoxic activity were determined in vitro against MDA-MB 231, MCF-7 and SK-N-MC cell lines using MTT assay. Among the tested compounds, the highest activity against MDA-MB 231 cells was achieved by 2-(3-bromo-5-methoxy-4-propoxybenzylidene)-6-(2-nitrobenzylidene)cyclohexanone (compound 5d). Whereas, compound 5j (the 3-nitro analog of compound 5d) was the most potent compound against MCF-7 and SK-N-MC cell lines. The results indicated that the cytotoxic activity profile against different tumor cells can be optimized by desired 4-alkoxy-3-bromo-5-methoxybenzylidene scaffold.
E,E-2-Benzylidene-6-(nitrobenzylidene)cyclohexanones: Syntheses, cytotoxicity and an examination of some of their electronic, steric, and hydrophobic properties
Das, Umashankar,Doroudi, Alireza,Das, Swagatika,Bandy, Brian,Balzarini, Jan,De Clercq, Erik,Dimmock, Jonathan R.
, p. 6261 - 6268 (2008/12/21)
Three series of structurally isomeric 2-benzylidene-6-(nitrobenzylidene) cyclohexanones 1-3 were prepared and evaluated against human Molt/C8 and CEM T-lymphocytes as well as murine L1210 cells. The IC50 values of the majority of compounds are
Synthesis of quinolines, 2-quinolones, phenanthridines, and 6(5H)-phenanthridinones via palladium[0]-mediated Ullmann cross-coupling of 1-bromo-2-nitroarenes with β-halo-enals, -enones, or -esters
Banwell, Martin G.,Lupton, David W.,Ma, Xinghua,Renner, Jens,Sydnes, Magne O.
, p. 2741 - 2744 (2007/10/03)
Palladium[0]-mediated Ullmann cross-coupling of 1-bromo-2-nitrobenzene (1 R = H) and its derivatives with a range of β-halo-enals, -enones, or -esters readily affords the corresponding β-aryl derivatives, which are converted into the corresponding quinolines, 2-quinolones, phenanthridines, or 6(5H)-phenanthridinones on reaction with dihydrogen in the presence of Pd on C or with TiCl3 in aqueous acetone.
