292038-16-5Relevant academic research and scientific papers
A new procedure for the enantioselective vinylogous aldol reaction of Chan's diene
Villano, Rosaria,Acocella, Maria Rosaria,Massa, Antonio,Palombi, Laura,Scettri, Arrigo
, p. 3332 - 3334 (2007/10/03)
Chiral δ-hydroxy-β-ketoesters are easily available through the enantioselective vinylogous aldol reaction of Chan's diene promoted by a SiCl4/chiral phosphoramide catalytic system. The procedure is conveniently exploited for a very rapid approach to (+)-kavain, a natural bio-active α-pyrone compound.
Enantioselective aldol condensation of 1,3-bis-(trimethylsilyloxy)-1-methoxy-buta-1,3-diene promoted by chiral Ti(IV)/BINOL complex
Soriente, Annunziata,De Rosa, Margherita,Villano, Rosaria,Scettri, Arrigo
, p. 2255 - 2258 (2007/10/03)
Enantiomerically enriched δ-hydroxy-β-ketoesters are easily available by aldol condensation of 1,3-bis-(trimethylsilyloxy)-1-methoxy-buta-1,3-diene in the presence of Ti(O-iPr)4/(S)-(-)-BINOL system. All reaction mixtures were separated by column chromatography and mostly isolated in moderate to good yields and all in high enantiomeric excesses. Copyright (C) 2000 Elsevier Science Ltd.
