2921-66-6Relevant academic research and scientific papers
Microwave-assisted direct esterification of cyclic phosphinic acids
Kiss, Nora Zsuzsa,Boettger, Eva,Drahos, Laszlo,Keglevich, Gyoergy
, p. 283 - 288 (2013)
It is known that phosphinic acids do not undergo direct esterification under conventional conditions. However, the reaction may take place on microwave irradiation. 1-Hydroxy-3-phospholene 1-oxides, 1-hydroxy-phospholane 1-oxides, and a 1-hydroxy-1,2,3,4,5,6-hexahydrophosphinine 1-oxide were esterified with n-pentanol, i-pentanol, n-octanol, and i-octanol(2-ethylhexanol). The phosphinates prepared in 50%-94% yield are all new compounds, and a number of them are useful intermediates.
Synthesis of Cyclic Phosphinates by Microwave-Assisted Ionic-Liquid-Promoted Alcoholysis
Drahos, László,Harsági, Nikoletta,Keglevich, Gy?rgy,Kiss, Nóra Zsuzsa
, (2021/06/21)
A series of 1-alkoxy-3-methyl- and 3,4-dimethyl-3-phospholene 1-oxides, as well as 1-alkoxy-3-methylphospholane 1-oxides were prepared in good yields by the microwave (MW)-assisted [bmim][PF 6]-catalyzed transesterification of the corresponding methyl or ethyl esters. The alcoholyses studied represent another case, where MW irradiation has had a crucial role on the course of the reaction. The method developed is an alternative possibility to other esterifications starting from the corresponding phosphinic chlorides and acids.
Hydrolysis and alcoholysis of phosphinates and phosphonates
Harsági, Nikoletta,Keglevich, Gy?rgy,Sz?ll?si, Betti,Varga, Petra Regina
, (2021/11/04)
Phosphinic and phosphonic acids useful intermediates and biologically active compounds may be prepared from their esters: phosphinates and phosphonates, respectively, by acid-catalyzed hydrolysis either on conventional heating or on MW irradiation. The transesterification of alkyl phosphinates took place only in the presence of suitable ionic liquids as the catalysts. In the cases of phenylphosphonates, depending on the nature of the ionic liquid, the formation of the ester was accompanied by the fission of the C–O bond.
Esterification of five-membered cyclic phosphinic acids under mild conditions using propylphosphonic anhydride (T3P)
Jablonkai, Erzsébet,Milen, Mátyás,Drahos, László,Keglevich, Gy?rgy
, p. 5873 - 5875 (2013/10/21)
1-Hydroxy-phospholene 1-oxides (1 and 3) and 1-hydroxy-phospholane oxides (5 and 7) undergo fast and efficient esterification with a series of alcohols, at room temperature, in the presence of 1.1 equiv of propylphosphonic anhydride (T3P).
