29211-05-0

Basic information

• Product Name: 2,6-di-tert-butyl-4-{[tert-butyl(hydroxy)amino]methylidene}cyclohexa-2,5-dien-1-one
• CAS NO: 29211-05-0
• Molecular Formula: C₁₉H₃₁NO₂
• Molecular Weight: 305.4549
• Mol File: 29211-05-0.mol

Chemical Properties

• Boiling Point: 399.6°C at 760 mmHg
• Flash Point: 195.5°C
• Density: 1.054g/cm³
• Vapor Pressure: 4.8E-08mmHg at 25°C
• Refractive Index: 1.558
• CAS DataBase Reference: 2,6-di-tert-butyl-4-{[tert-butyl(hydroxy)amino]methylidene}cyclohexa-2,5-dien-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,6-di-tert-butyl-4-{[tert-butyl(hydroxy)amino]methylidene}cyclohexa-2,5-dien-1-one(29211-05-0)
• EPA Substance Registry System: 2,6-di-tert-butyl-4-{[tert-butyl(hydroxy)amino]methylidene}cyclohexa-2,5-dien-1-one(29211-05-0)

Safety Data

• Hazardous Substances Data: 29211-05-0(Hazardous Substances Data)

Usage

Chemical compound

2,6-di-tert-butyl-4-[tert-butyl(hydroxy)amino]methylidenecyclohexa-2,5-dien-1-one
Derivative of cyclohexa-2,5-dien-1-one
Contains two tert-butyl groups and a hydroxy amino group
Carbonyl compound
Stable and versatile
Potentially valuable for various chemical applications
Potential uses in pharmaceuticals and organic synthesis
Unique structure and properties for the development of new drugs and materials

Upstream product

• 57497-39-9 N-tertbutylhydroxylamine hydrochloride 
• 1620-98-0 3,5-di-t-butyl-4-hydroxybenzaldehyde 
• 54749-42-7 2,6-Di-tert-butyl-(N-tert-butylnitrono)phenoxyl 

Downstream Products

• 93959-02-5 3,5-Di-tert-butyl-4-hydroxy-benzoesaeure-(N-benzoyloxy-N-tert-butyl)-amid 
• 93214-34-7 α-(4-Cyanoisopropyl-2,6-di-tert-butyl-1-oxo-2,5-cyclohexadienyl)-N-tert-butylnitron 
• 93214-66-5 α-(4-tert-Butoxy-2,6-di-tert-butyl-1-oxo-2,5-cyclohexadienyl)-N-tert-butylnitron 
• 93214-35-8 α-(2-Acetoxy-2,6-di-tert-butyl-1-oxo-3,5-cyclohexadienyl)-N-tert-butylnitron 
• 54749-42-7 2,6-Di-tert-butyl-(N-tert-butylnitrono)phenoxyl 
• 54749-42-7 2,6-di-tert-butyl-4-[(tert-butylimino)methyl]phenoxy N-oxide 

Relevant articles and documents

α-aryl-N-alkyl nitrones, as potential agents for stroke treatment: Synthesis, theoretical calculations, antioxidant, anti-inflammatory, neuroprotective, and brain-blood barrier permeability properties

We report the synthesis, theoretical calculations, the antioxidant, anti-inflammatory, and neuroprotective properties, and the ability to cross the blood-brain barrier (BBB) of (Z)-α-aryl and heteroaryl-N-alkyl nitrones as potential agents for stroke trea

COMPOSITIONS COMPRISING A NITRONE COMPOUND FOR USE IN TREATING UVEITIS

Ophthalmic pharmaceutical compositions containing a pharmaceutically acceptable ophthalmic carrier and an inflammation-treating amount of a nitrone compound are disclosed. Also disclosed are methods for treating ocular inflammation conditions, such as uveitis, using pharmaceutical compositions.

Use of aryl nitrone compounds in methods for treating neuropathic pain

3,4,5-trisubstituted aryl nitrone compounds having the formula: where R1—R4 are as defined in the specification are useful as therapeutics for neuropathic pain conditions in mammals.

Reactions of the 2,6-Di-tert-butyl-4-(N-tert-butylnitrono)-phenoxyl Radical

The title compound, a phenoxyl radical containing a nitrono group, reacts with alcohols and tert-butylhydroperoxide yielding phenol and products of secondary solvent reactions.The reactions with lead tetraacetate, tert.-butoxy and 2-cyanoisopropyl radicals give high yields of cyclohexadienone adducts (6, 7 and 10) containing unchanged nitrono function.The reaction with dibenzoylperoxide, however, leads to the modification of the nitrono group yielding the N-benzoyloxycarboxamide (8).In the acidic decomposition of the tert-butoxy radical adduct we suggest a nitrenium ion (16) as an intermediate.