29220-54-0Relevant academic research and scientific papers
Synthesis of nucleoside α-thiotriphosphates via an oxathiaphospholane approach
Misiura, Konrad,Szymanowicz, Daria,Stec, Wojciech J.
, p. 2217 - 2220 (2007/10/03)
(Chemical Equation Presented) Nucleoside 5′-O-(α- thiotriphosphates) were obtained in reactions of the appropriate nucleoside 5′-O-(2-thio-1,3,2-oxathiaphospholanes) with pyrophosphate in the presence of DBU. The presented method allows also for preparation of α-seleno congeners and corresponding α-modified diphosphates.
SIMPLE SYNTHESIS AND SEPARATION OF THE DIASTEREOMERS OF α-THIO ANALOGS OF RIBO- AND DEOXYRIBO- DI- AND TRIPHOSPHATES
Goody, R. S.,Isakov, M.
, p. 3599 - 3602 (2007/10/02)
Nucleoside 5'-O-(1-thiodi-) and triphosphates can be obtained in yields of up to 45percent directly from the nucleosides.Their diastereomers can be separated by preparative reversed phase chromatography.
