2923-41-3

Usage

InChI:InChI=1/C7H4F3.ClH.Mg/c8-7(9,10)6-4-2-1-3-5-6;;/h2-5H;1H;/q;;+1/p-1/rC7H4ClF3Mg/c8-12-6-3-1-5(2-4-6)7(9,10)11/h1-4H

Upstream product

• 7439-95-4 magnesium 
• 98-56-6 4-chlorobenzotrifluoride 
• 402-43-7 p-trifluoromethylphenyl bromide 
• 455-13-0 4-Iodobenzotrifluoride 

Downstream Products

• 70841-21-3 10-(4-trifluoromethyl-phenyl)-10H-phenoxarsine 
• 64268-53-7 10-(4-trifluoromethyl-phenyl)-5,10-dihydro-phenarsazine 
• 581-80-6 4,4'-bis(trifluoromethyl)biphenyl 
• 132115-87-8 (4-trifluoromethyl-phenyl)carbonyl-acetic acid methyl ester 
• 2967-66-0 methyl 4-(trifluoromethyl)benzoate 
• 455-24-3 4-trifluoromethylbenzoic acid 
• 306298-03-3 C₂₁H₂₉F₃N₂O₂ 

Relevant academic research and scientific papers

Chemical tracer agent for fracturing as well as preparation method and application thereof

The invention relates to a chemical tracer for fracturing and a preparation method and application thereof. The chemical tracer agent is fluoromethyl benzoic acid. The preparation method of the chemical tracer takes p-chlorofluoromethyl benzene as an initial raw material, and comprises a preparation step of a fluoromethyl benzene Grignard reagent, a preparation step of fluoromethyl benzoate and a preparation step of fluoromethyl benzoic acid. The invention further provides application of p-fluoromethyl benzoic acid as a chemical tracer in oil exploitation, trace detection can be realized, and the detection precision is improved.

Preparation of Trifluoromethylphenyl Magnesium Halides in the Presence of LiCl and Synthesis of 2′-Trifluoromethyl-Aromatic Ketones

The effect of LiCl-promoted insertion of magnesium turnings into halogenated-trifluoromethylbenzenes for Grignard reagent synthesis was investigated. In the presence of less than 1.0 equiv of LiCl, chloro(trifluoromethyl)benzene Grignard reagents were easily generated. The 2-trifluoromethylphenyl magnesium chloride Grignard reagent was obtained in high yield and 2′-trifluoromethyl-substituted aromatic ketone was synthesized through reaction of the obtained Grignard reagent with a carboxylic anhydride in an 83% yield.

Formation of 2-trifluoromethylphenyl grignard reagent via magnesium-halogen exchange: Process safety evaluation and concentration effect

The thermal stability profile for a solution of 2-trifluoromethylphenyl magnesium chloride at 1.5Mconcentration in THF was determined using an Advanced Reactive System Screening Tool (ARSST). The solution generated by employing Knochel's magnesium-halogen

PROCESS FOR PRODUCTION OF BIPHENYL DERIVATIVES

A process for the production of biphenyl derivatives represented by the general formula (1), which is characterized by comprising reacting the chlorine atom of a benzene derivative represented by the general formula (2) with metallic magnesium to form a Grignard reagent and coupling two molecules of the Grignard reagent with each other in the presence of a catalyst and which is excellent in industrial productivity by virtue of its using inexpensive and easily available raw materials. (1) (2) (wherein A’s are at least one member selected from between trifluoromethyl and fluoro; and n is an integer of 1 to 4)

Piperazine derivatives useful as CCR5 antagonists

The use of CCR5 antagonists of the formula or a pharmaceutically acceptable salt thereof, wherein R is optionally substituted phenyl, pyridyl, thiophenyl or naphthyl; R1is hydrogen or alkyl; R2is substituted phenyl, substituted heter