2923-83-3Relevant academic research and scientific papers
Interaction of cycloSal-pronucleotides with cholinesterases from different origins. A structure-activity relationship
Meier, Chris,Ducho, Christian,G?rbig, Ulf,Esnouf, Robert,Balzarini, Jan
, p. 2839 - 2852 (2004)
A large number of cycloSal-nucleotide triesters 1-49 have been studied concerning their ability to inhibit cholinesterases of different origins as well as to inhibit HIV replication in cell culture. It was shown that none of the triesters showed inhibitor
PRODRUGS OF AZACITIDINE 5'-PHOSPHATE
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Page/Page column 14, (2011/12/14)
The present disclosure relates to analogs or derivatives of azacitidine with improved pharmaceutical properties and methods for the treatment of proliferative disease utilizing said analogs or derivatives.
3,5-Di-(tert-Butyl)-6-fluoro-cycloSal-d4TMP - A Pronucleotide with a Considerably Improved Masking Group
Ducho, Christian,Wendicke, Silke,Goerbig, Ulf,Balzarini, Jan,Meier, Chris
, p. 4786 - 4791 (2007/10/03)
A new, considerably improved cycloSal masking group has been developed. This new group combines four desirable properties and has been attached to the anti-HIV drug 2′,3′-dideoxy-2′,3′-didehydrothymidine (d4T, 1) to give 3,5-(di-tert-butyl)-6-fluoro-cycloSal-d4TMP (2i). This phosphate triester has a reasonable chemical half-life, highly selectively released d4TMP, has poor - if any - inhibitory effect on butyrylcholinesterase (BChE), and achieved the TK-bypass. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003).
