2923-90-2

Usage

Uses

Used in Research Applications:
Uridine, 2'-deoxy-2'-fluoro-5'-O-(triphenylmethyl)is used as a research compound for the synthesis of modified nucleic acids. The modification allows for the study of nucleic acid structure and function, providing insights into their biological roles and potential applications.
Used in Pharmaceutical Development:
Uridine, 2'-deoxy-2'-fluoro-5'-O-(triphenylmethyl)is used as a starting material in the development of nucleoside analogs. These analogs have potential therapeutic applications, as the altered biochemical properties may lead to the creation of new drugs with improved efficacy or reduced side effects.
Used in Biochemistry:
Uridine, 2'-deoxy-2'-fluoro-5'-O-(triphenylmethyl)is used as a biochemical tool to investigate the interactions between nucleic acids and other biomolecules. The presence of the fluorine atom and the triphenylmethyl group can affect the binding and reactivity of the compound, offering a means to explore the mechanisms of nucleic acid interactions in biological systems.

Upstream product

• 76-83-5 trityl chloride 
• 56287-17-3 2'-deoxy-2'-fluorouridine 
• 16731-33-2 1-(3',5'-di-O-trityl-β-D-arabinofuranosyl)uracil 

Downstream Products

• 127840-97-5 1-(2-deoxy-2-fluoro-5-O-trityl-β-D-xylofuranosyl)uracil 
• 127841-13-8 4-Amino-1-((2R,3S,4R,5R)-3,4-difluoro-5-trityloxymethyl-tetrahydro-furan-2-yl)-1H-pyrimidin-2-one 
• 127840-98-6 1-(2,3-dideoxy-2,3-difluoro-5-O-trityl-β-D-ribofuranosyl)uracil 
• 127841-02-5 3'-azido-2'-fluoro-5'-O-trityl-2',3'-dideoxyuridine 
• 127841-01-4 1-(2-deoxy-2-fluoro-3-O-mesyl-5-O-trityl-β-D-xylofuranosyl)uracyl 

Relevant academic research and scientific papers

Anti-flavivirus Activity of Different Tritylated Pyrimidine and Purine Nucleoside Analogues

A series of tritylated and dimethoxytritylated analogues of selected pyrimidine and purine nucleosides were synthesized and evaluated for their in vitro inhibitory activity against two important members of the genus Flavivirus in the Flaviviridae family, the yellow fever (YFV) and dengue viruses (DENV). Among all compounds tested, the 5′-O-tritylated and the 5′-O-dimethoxytritylated 5-fluorouridine derivatives exerted potency against YFV. Interestingly in the series of purine analogues, the 5′O, N-bis-tritylated fludarabine derivative revealed strong inhibitory activity against DENV at μm concentrations, however significantly weaker potency against YFV.

2,3'-DIFLUORO- AND 3'-AZIDO-2'-FLUORO SUBSTITUTED DIDEOXYPYRIMIDINES AS POTENTIAL ANTI-HIV AGENTS

2'-Deoxy-2'-fluorouridine (2) was obtained by reaction of the arabinofuranosyl nucleoside 1 with diethylaminosulfur trifluoride followed by detritylation.After inversion of the configuration at the 3'-position, 4 was used as starting material for the preparation of the 2',3'-disubstituted derivatives 6, 7, 8 and 10.