29232-73-3

Basic information

• Product Name: methyl 3,5-bis(cyanomethyl)benzoate
• Synonyms: methyl 3,5-bis(cyanomethyl)benzoate
• CAS NO: 29232-73-3
• Molecular Formula: C12H10N2O2
• Molecular Weight: 214.22
• Mol File: 29232-73-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: methyl 3,5-bis(cyanomethyl)benzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3,5-bis(cyanomethyl)benzoate(29232-73-3)
• EPA Substance Registry System: methyl 3,5-bis(cyanomethyl)benzoate(29232-73-3)

Safety Data

• Hazardous Substances Data: 29232-73-3(Hazardous Substances Data)

Upstream product

• 25081-39-4 methyl 3,5-dimethylbenzoate 
• 29333-41-3 methyl 3,5-bis(bromomethyl)benzoate 
• 151-50-8 potassium cyanide 

Relevant articles and documents

A method of synthesis of aromatase inhibitors

The invention discloses a method for synthesizing an aromatase inhibitor anastrozole. A synthesis route comprises the steps: with 3, 5-dimethylbenzoate as a starting material, carrying out bromination, cyanation and methylation to obtain 3, 5-bis (2-cyano-2-yl) benzoate, reducing the intermediate to obtain 3,5-bis (2-cyano-2-yl) benzaldehyde, and carrying out a reductive amination reaction on the generated intermediate and 1.24-triazole to obtain anastrozole. The method has the advantages of easiness in operation, mild reaction conditions, high yield, high product purity and the like, and is suitable for industrial production of anastrozole.

PHENYL-SULFAMATES AS AROMATASE INHIBITORS

There is provided a compound of Formula (I) wherein X, Y and Z are each independently of each other an optional linker group; R, is a ring system; R2 is selected from hydrocarbyl groups, oxyhydrocarbyl groups, cyano (CN), nitro (-NO2) and halogens; R3 and R4 are independently selected from H and hydrocarbyl, ring A and B are independently optionally further substituted.