292600-24-9

Upstream product

• 292600-23-8 methyl 2-methyl-2-(5-nitropyridin-2-yl)propionate 

Downstream Products

• 292609-78-0 5-[2-(2-aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-3-[1-methyl-2-(2-pyridin-4-yl-ethylamino)-ethyl]-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester 
• 292600-33-0 5-[2-(2-aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-3-(2-benzyloxy-1-methyl-ethyl)-2-(3,5-dimethyl-phenyl)-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester 
• 292600-35-2 5-[2-(2-aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-3-(2-azido-1-methyl-ethyl)-2-(3,5-dimethyl-phenyl)-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester 
• 292600-30-7 (S)-1-(2-Azabicyclo[2.2.2]oct-2-yl)-2-[3-(2-benzyloxy-1-methylethyl)-2-triethylsilyl-1H-pyrrolo[2,3-c]pyridin-5-yl]-2-methylpropan-1-one 
• 292600-34-1 5-[2-(2-aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-3-(2-hydroxy-1-methyl-ethyl)-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester 
• 292600-36-3 3-(2-amino-1-methyl-ethyl)-5-[2-(2-aza-bicyclo[2.2.2]oct-2-yl)-1,1-dimethyl-2-oxo-ethyl]-2-(3,5-dimethyl-phenyl)-pyrrolo[2,3-c]pyridine-1-carboxylic acid tert-butyl ester 
• 292600-32-9 (S)-1-(2-Azabicyclo[2.2.2]oct-2-yl)-2-[3-(2-benzyloxy-1-methylethyl)-2-(3,5-dimethylphenyl)-1H-pyrrolo[2,3-c]pyridin-5-yl]-2-methylpropan-1-one 
• 292600-31-8 (S)-1-(2-Azabicyclo[2.2.2]oct-2-yl)-2-[3-(2-benzyloxy-1-methylethyl)-2-iodo-1H-pyrrolo[2,3-c]pyridin-5-yl]-2-methyl propan-1-one 

Relevant academic research and scientific papers

Total syntheses of 6- and 7-azaindole derived GnRH antagonists

The palladium(0)-catalyzed heteroannulation of a triethylsilyl alkyne and an ortho-aminoiodopyridine derivative is used as the key step in a highly convergent route to 6- and 7-azaindoles of biological interest.

6-AZAINDOLE COMPOUNDS AS ANTAGONISTS OF GONADOTROPIN RELEASING HORMONE

There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which are useful as antagonists of GnRH and as such may be useful for the treatment of a variety of sex-hormone related and other conditions in both men and women.