292610-93-6

Basic information

• Product Name: 4-methyl-4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-nicotinanilide monohydrochloride
• Synonyms: 4-methyl-4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-nicotinanilide monohydrochloride
• CAS NO: 292610-93-6
• Molecular Weight: 414.31
• Mol File: 292610-93-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-methyl-4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-nicotinanilide monohydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-nicotinanilide monohydrochloride(292610-93-6)
• EPA Substance Registry System: 4-methyl-4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-nicotinanilide monohydrochloride(292610-93-6)

Safety Data

• Hazardous Substances Data: 292610-93-6(Hazardous Substances Data)

Upstream product

• 94015-05-1 4-methylpyridine-3-carboxylic acid hydrochloride 
• 123066-64-8 4-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl] aniline 

Relevant articles and documents

Novel potent and selective Ca2+ release-activated Ca2+ (CRAC) channel inhibitors. Part 3: Synthesis and CRAC channel inhibitory activity of 4′-[(trifluoromethyl)pyrazol-1-yl]carboxanilides

From a series of 4'-[(trifluoromethyl)pyrazol-1-yl]carboxanilides derived from 4-methyl-4'-[3,5-bis(trifluoromethyl)-1H-pyrazol-1-yl]-1,2,3-thiadiazole-5-carboxanilide, one inhibited thapsigargin-induced Ca2+ influx in Jurkat T cells (IC50 = 77 nM) and exhibited high selectivity for the CRAC channel over the VOC channel (index: >130). Another acted as an inhibitor for both T lymphocyte activation-induced diseases and ovalbumin-induced airway eosinophilia in rats (ED50 = 1.3 mg/kg) p.o.