292620-48-5Relevant academic research and scientific papers
Synthesis of L-(+)-3-(3-hydroxy-4-pivaloyloxybenzyl)-2,5-diketomorpholine as potential prodrug of L-dopa
Cingolani, Gian Mario,Di Stefano, Antonio,Mosciatti, Barbara,Napolitani, Fabrizio,Giorgioni, Gianfabio,Ricciutelli, Massimo,Claudi, Francesco
, p. 1385 - 1388 (2000)
The synthesis and in vitro chemical and enzymatic stability of L-(+)-3-(3-hydroxy-4-pivaloyloxybenzyl)-2,5-diketomorpholine (9) as L-Dopa prodrug are described. Prodrug 9 possesses a good lipophilicity (log P=2.153 ± 0.017), is stable in aqueous buffer solutions (pH 1.3 and 7.4), and in 80% rat and human plasma it is turned into L-Dopa. (C) 2000 Elsevier Science Ltd. All rights reserved.
