292824-29-4Relevant academic research and scientific papers
Short, enantioselective total synthesis of aflatoxin B2 using an asymmetric [3+2]-cycloaddition step
Zhou, Gang,Corey
, p. 11958 - 11959 (2007/10/03)
A highly enantioselective [3+2]-cycloaddition reaction of 2,3-dihydrofuran with 1,4-benzoquinones using a chiral oxazaborolidinium triflimidate as catalyst has been developed which allows rapid access to a variety of chiral phenolic tricycles (enantiomeric excesses ranging from 91 to 98%). The utility of this new methodology is demonstrated by a short synthesis of the important pentacyclic natural product, aflatoxin B2. This exploratory study indicates that an even broader application of these catalysts to enantioselective cycloadditions may be possible. Copyright
