29283-59-8

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 77381-24-9 2,3-Bis-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-succinaldehyde 
• 29283-63-4 1,4-Bis<4-methoxyphenyl>-butadiene-2,3-dicarboxylic acid 

Downstream Products

• 15828-76-9 1-(4-methoxyphenyl)-7-methoxy-2,3-naphthalenedicarboxylic anhydride 
• 29283-61-2 cis,trans-Di-p-methoxybenzylidensuccinanhydrid 
• 29283-60-1 bis-(p-methoxybenzylidene)succinic anhydrides 

Relevant academic research and scientific papers

Unusual visible-light photolytic cleavage of tertiary amides during the synthesis of cyclolignans related to podophyllotoxin

During the attempted photochemical cyclization of 2,3-bisbenzylidene-γ-hydroxybutyric acid cyclic amide ester, it was observed that a γ-butyrolactone ring was formed, which was concurrent with the release of the amine fragment from the amide. The process occurs with high yield giving rise to the formation of β-apopicropodophyllin and its regioisomer. Additional experiments confirmed the photochemical nature of this transformation, and that it is independent from the photocyclization of the benzylidene groups – a typical reactivity for the members of the fulgide family. In contrast to the latter UV-driven cyclization, the photochemical cleavage of the amide was proven to proceed under irradiation with visible light.