292853-20-4

Upstream product

• 126-81-8 dimedone 
• 105-45-3 acetoacetic acid methyl ester 
• 1122-91-4 4-bromo-benzaldehyde 
• 141-97-9 ethyl acetoacetate 

Downstream Products

• 1408382-58-0 C₂₆H₃₃NO₃ 
• 1394961-43-3 C₂₇H₂₉NO₃ 
• 1394961-44-4 C₂₇H₂₆F₃NO₃ 
• 1349689-17-3 C₂₆H₂₆ClNO₃ 
• 1408382-67-1 C₂₇H₂₉NO₃ 
• 1408382-68-2 C₂₆H₂₆FNO₃ 

Relevant academic research and scientific papers

Sulfuric acid heterogenized on magnetic Fe3O4 nanoparticles: A new and efficient magnetically reusable catalyst for condensation reactions

Immobilized sulfuric acid on magnetic Fe3O4 nanoparticles (Fe3O4 MNPs-OSO3H) as a new solid acid nanocomposite was successfully synthesized and its catalytic activity in a series of condensation reactions was studied. High catalytic activity, simple separation from reaction mixture by an external magnet and good reusability are several eco-friendly advantages of this catalytic system. It is noteworthy that this catalytic system is applicable to a wide range of spectrum of aromatic aldehydes, and the desired products were obtained in good to excellent yields under mild conditions. The use of ecofriendly solvents makes also this synthetic protocol ideal and fascinating from the environmental point of view.

Sucrose chelated auto combustion synthesis of BiFeO3 nanoparticles: Magnetically recoverable catalyst for the one-pot synthesis of polyhydroquinoline

Sucrose chelated Bismuth ferrite (BiFeO3) nanoparticles as a novel heterogeneous catalyst was synthesized by an auto combustion route. Different calcination temperatures (150?°C, 450?°C, 550?°C, 650?°C, 750?°C and 850?°C) have been employed to obtain single phased BiFeO3 nanoparticles. The perovskite structure formation and disappearance of organic phase (sucrose) was obtained by Fourier transform infrared spectroscopy (FT-IR). Phase determination and structural characterization was carried out by powder X-ray diffraction (XRD). The magnetic properties were analyzed by vibrating sample magnetometer (VSM) whereas surface area/pore volume was obtained by Brunauer–Emmett–Teller (BET). Transmission electron microscope (TEM) analyzed the particles size and morphology. Thermal stability was investigated by thermogravimetric analysis (TGA) and determination of constituent elements was carried out by X-ray Photo-Electron Spectroscopy (XPS). Raman spectroscopy confirmed the perovskite structure of the synthesized materials. The BiFeO3 nanoparticles so obtained were employed as heterogeneous catalyst for the synthesis of polyhydroquinoline derivatives. All the polyhydroquinoline derivatives were characterized by Fourier transform infrared spectroscopy (FT-IR) and Nuclear magnetic resonance spectroscopy (1H NMR). For the very first time ever we have used BiFeO3 as a recyclable magnetic nanocatalyst in the one-pot four component cyclization reaction of benzaldehyde, ethylacetoacetate/methylacetoacetate, dimedone/cyclohexane-1,3-dione, and ammonium acetate for the synthesis of polyhydroquinoline derivatives without solvent under refluxing conditions to provide excellent yields of products. BiFeO3 nanocatalyst (without any functionalization/surface coatings) shows easy magnetic separation, recyclability, reusability along with excellent yield of polyhydroquinoline derivatives in an economic and benign way.

Novel magnetic nanoparticles with ionic liquid tags as a reusable catalyst in the synthesis of polyhydroquinolines

In this study, we have introduced {Fe3O4SiO2(CH2)3Im}C(NO2)3 as a novel and heterogeneous reusable catalyst for the four component preparation of polyhydroquinoline derivatives under mild and eco-friendly reaction conditions. The structural confirmation of the novel heterogeneous reusable promoter was fully made using FT-IR, X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), energy-dispersive spectroscopy (EDS) elemental mapping analysis, high resolution transmission electron microscopy (HRTEM), thermogravimetry (TG), derivative thermal gravimetric (DTG), differential thermal (DTA) and vibrating sample magnetometer (VSM) analyses. The nanomagnetic heterogeneous catalyst was successfully applied for the synthesis of polyhydroquinoline derivatives via a four component condensation of a good range of aryl aldehydes, dimedone, ethyl acetoacetate or methyl acetoacetate as a β-ketoester, and ammonium acetate as a nitrogen source under solvent free conditions. Moreover, experimental evidence has demonstrated that {Fe3O4@SiO2@(CH2)3Im}C(NO2)3 could act as a recoverable nanomagnetic and reusable catalyst without any considerable drop in the yield and the reaction time for at least eight times.

One-pot multicomponent synthesis hexahydroquinoline derivatives in Triton X-100 aqueous micellar media

A facile and efficient synthesis of hexahydroquinoline derivatives (5a-o) was reported via a four-component condensation reaction of aldehydes, dimedone, methyl aceto acetate and ammonium acetate in the presence of Triton X-100 in water at room temperature. The use of just 20 mol % of Triton X-100 in water solvent is sufficient. The FT-IR, 19F NMR, 1H NMR, 13C NMR spectra and elemental analysis confirm the structure of the compounds.

Magnetically recyclable magnetite-ceria (Nanocat-Fe-Ce) nanocatalyst-applications in multicomponent reactions under benign conditions

A novel magnetite nanoparticle-supported ceria catalyst (Nanocat-Fe-Ce) has been successfully prepared by a simple impregnation method and was characterized by XRD, SIMS, FEG-SEM-EDS, and TEM. The exact nature of Nanocat-Fe-Ce was confirmed by X-ray photoelectron spectroscopy and it is noted that CeO2 nanoparticles are supported on magnetite, with evidence of secondary ion mass spectrometry. Catalytic activity of the nano-catalyst was explored for the synthesis of dihydropyridines under benign conditions; a greener protocol is described that provides a simple and efficient method for the synthesis of functionalized 1,4-dihydropyridines using a recyclable nanocatalyst. Notably, 5.22 mol% of the catalyst is sufficient to catalyze the multicomponent reaction in ethanolic medium at room temperature. Importantly, the catalyst could be easily separated from the reaction mixture by using an external magnet and recycled several times without loss of activity.

Vanadatesulfuric acid-catalyzed novel and eco-benign one-pot synthesis of polyhydroquinoline derivatives under solvent-free conditions

A novel and green approach for efficient and rapid synthesis of biologically active polyhydroquinoline derivatives via unsymmetric Hantzsch reaction using Vanadatesulfuric acid (VSA) as a new and recyclable catalyst under solvent-free conditions was repor

Silica sulfuric acid: An efficient and versatile catalyst for one-pot synthesis of substituted 5-Oxo-1,4,5,6,7,8-hexahydroquinoline derivatives

An easy method for synthesis of substituted 5-oxo-1,4,5,6,7,8- hexahydroquinoline derivatives from 5,5-dimethyl-1,3-cyclohexanedione or 1,3-cyclohexanedione, arylaldehyde, methyl acetoacetate and ammonium acetate using silica sulfuric acid as catalyst is