29310-39-2Relevant academic research and scientific papers
Synthesis of 3D-Rich Heterocycles: Hexahydropyrazolo[1,5-A]pyridin-2(1H)-ones and Octahydro-2H-2a,2a1-diazacyclopenta[cd]inden-2-ones
Pu?avec Kirar, Eva,Drev, Miha,Mirnik, Jona,Gro?elj, Uro?,Golobi?, Amalija,Dahmann, Georg,Po?gan, Franc,?tefane, Bogdan,Svete, Jurij
, p. 8920 - 8933 (2016/10/14)
Two cyclic azomethine imines, 7-methyl- and 7-phenyl-2-oxo-Δ7-hexahydropyrazolo[1,5-A]pyridin-8-ium-1-ide, were prepared in seven steps from the respective commercially available δ-keto acids. The addition of Grignard reagents followed by N-Alkylation at position 1 afforded the 1,7,7-trisubstituted hexahydropyrazolo[1,5-A]pyridin-2(1H)-ones, whereas 1,3-dipolar cycloadditions of these dipoles to typical acetylenic and olefinic dipolarophiles gave 4a-substituted 2a,2a1-diazacyclopenta[cd]indene derivatives as the first representatives of a novel heterocyclic system. Regio- and stereoselectivity as well as the mechanism of these [3 + 2]-cycloadditions were evaluated using computational and experimental methods. The data obtained were in agreement with the polar concerted cycloaddition mechanism via the energetically favorable syn/endo-transition states.
8-substituted-dibenz[b,f][1,4]oxazepine-10(11)-carboxylic acid, substituted hydrazides, pharmaceutical compositions, and methods for treating pain
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, (2008/06/13)
The present invention provides substituted dibenzoxazepine compounds of Formula I: STR1 wherein X is STR2 which are useful as analgesic agents for the treatment of pain, pharmaceutical compositions comprising a therapeutically-effective amount of a compound of Formula I in combination with a pharmaceutically-acceptable carrier, and a method for eliminating or ameliorating pain in an animal comprising administering a therapeutically-effective amount of a compound of Formula I to the animal.
Two convenient syntheses of brevicomin
Dandge, Chitra N,Naik, D G,Kapadi, A H
, p. 617 - 619 (2007/10/02)
Synthesis of brevicomin, 7-ethyl-7-methyl-6,8-dioxabicyclooctane (1), the aggregation pheromone of Western pine beetle, Dendroctonus brevicomis, by simple routes is described.
Decarbonylation of Tetrahydrofuran-2-carboxylic Acids and Tetrahydropyrane-2-carboxylic Acids in Concentrated Sulfuric acid: Formation of Oxonium Ions
Bates, Hans Aaron
, p. 2490 - 2493 (2007/10/02)
Tetrahydrofuran-2-carboxylic acids 1, 3, and 5 readily decarbonylate in 96percent sulfuric acid, generating stable oxonium ions 2, 4, and 6, respectively.Analogously, tetrahydropyran-2-carboxylic acids 7, 9, 12, and 14a produce oxonium ions 8, 10, 13, and 15, respectively.These oxonium ions are quite stable, with the exception of 10, which partially isomerizes to 11, and 13, which rearranges to ions 17 and 21.Details in the transformation of oxonium ion 15 into lactone 23 by way of open chain acid 22a were elucidated.
