293300-22-8Relevant academic research and scientific papers
5-alkyl-6-benzyl-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones, a series of anti-HIV-1 agents of the dihydro-alkoxy-benzyl-oxopyrimidine family with peculiar structure - Activity relationship profile
Nawrozkij, Maxim B.,Rotili, Dante,Tarantino, Domenico,Botta, Giorgia,Eremiychuk, Alexandre S.,Musmuca, Ira,Ragno, Rino,Samuele, Alberta,Zanoli, Samantha,Armand-Ugón, Mercedes,Clotet-Codina, Imma,Novakov, Ivan A.,Orlinson, Boris S.,Maga, Giovanni,Esté, José A.,Artico, Marino,Mai, Antonello
experimental part, p. 4641 - 4652 (2009/07/04)
A series of dihydro-alkylthio-benzyl-oxopyrimidines (S-DABOs) bearing a 2-aryl-2-oxoethylsulfanyl chain at pyrimidine C2, an alkyl group at C5, and a 2,6-dichloro-, 2-chloro-6-fluoro-, and 2,6-difluoro-benzyl substitution at C6 (oxophenethyl-S-DABOs, 6-8)
Does the 2-methylthiomethyl substituent really confer high anti-HIV-1 activity to S-DABOs?
Sbardella, Gianluca,Mai, Antonello,Artico, Marino,Massa, Silvio,Marceddu, Tiziana,Vargiu, Laura,Marongiu, Maria Elena,La Colla, Paolo
, p. 30 - 39 (2007/10/03)
S-DABO derivatives containing the methylthiomethyl (MTM) group have been synthesized and tested for anti-HIV-1 activity in cell-based assay (MTT and p24 assays) and for their capability to target the HIV-1 reverse transcriptase in enzyme assays. Data of experiments lead to the conclusion that the introduction of a 2-MTM-thio side chain is not sufficient per se to significantly increase S-DABO's potency. Nevertheless, potent MTM-S-DABOs can be obtained by introducing a 2,6-difluorophenylmethyl moiety as a C-6 substituent.
