293301-29-8

Basic information

• Product Name: 2,7-Difluoro-3-(3,5-dimethoxyphenyl)-1,6-naphthyridine
• Synonyms: 2,7-Difluoro-3-(3,5-dimethoxyphenyl)-1,6-naphthyridine
• CAS NO: 293301-29-8
• Molecular Weight: 302.28
• Mol File: 293301-29-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2,7-Difluoro-3-(3,5-dimethoxyphenyl)-1,6-naphthyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,7-Difluoro-3-(3,5-dimethoxyphenyl)-1,6-naphthyridine(293301-29-8)
• EPA Substance Registry System: 2,7-Difluoro-3-(3,5-dimethoxyphenyl)-1,6-naphthyridine(293301-29-8)

Safety Data

• Hazardous Substances Data: 293301-29-8(Hazardous Substances Data)

Upstream product

• 179343-43-2 4,6-Diaminonicotinaldehyde 
• 13388-75-5 3,5-dimethoxyphenylacetonitrile 
• 293301-09-4 3-(3,5-Dimethoxyphenyl)-1,6-naphthyridine-2,7-diamine 

Relevant articles and documents

Synthesis of 7-substituted 3-aryl-l,6-naphthyridin-2-amines and 7-substituted 3-aryl-l,6-naphthyridin-2(1H)-ones via diazotization of 3-aryl-l ,6-naphthyridine-2,7-diamines

The preparation of 3-aryl-7-halo-l,6-naphthyridin-2-amines and 3-aryl-7-halo-l,6-naphthyridin-2(1H)-ones from the diazotization of 3-aryl-l,6-naphthyridine-2,7-diamines is reported. The reactions were investigated in various solvents (concentrated HC1, 50% HBF4, 70% HF-pyridine, 20% and 90% H2SO4, dilute HC;, and neat TFA). By appropriate choice of solvent and other conditions, good yields of the target compounds could be obtained, although in some cases a variety of different side products was also produced. Subsequent displacement of the 7-halogen substituents with alkylamines provides a route to more complex 7-substituted 1,6-naphthyridine derivatives that are potential tyrosine kinase inhibitors. The Royal Society of Chemistry 2000.