293313-39-0

Basic information

• Product Name: Propanedioic acid, 2-cyclohexen-1-yl-2-propynyl-, dimethyl ester
• CAS NO: 293313-39-0
• Molecular Formula: C14H18O4
• Molecular Weight: 250.295
• Mol File: 293313-39-0.mol

Chemical Properties

• CAS DataBase Reference: Propanedioic acid, 2-cyclohexen-1-yl-2-propynyl-, dimethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Propanedioic acid, 2-cyclohexen-1-yl-2-propynyl-, dimethyl ester(293313-39-0)
• EPA Substance Registry System: Propanedioic acid, 2-cyclohexen-1-yl-2-propynyl-, dimethyl ester(293313-39-0)

Safety Data

• Hazardous Substances Data: 293313-39-0(Hazardous Substances Data)

Upstream product

• 108-59-8 malonic acid dimethyl ester 
• 95124-07-5 dimethyl (prop-2-yn-1-yl)malonate 
• 1521-51-3 rac-3-bromocyclohexene 
• 34939-28-1 dimethyl 2-(cyclohex-2-en-1-yl)malonate 
• 106-96-7 propargyl bromide 

Downstream Products

• 1446620-37-6 C₁₂H₁₆O₂ 
• 857335-70-7 dimethyl 2-(2-cyclohexen-1-yl)-2-(3-phenyl-2-propynyl)malonate 

Relevant articles and documents

Complementary Reactivity of 1,6-Enynes with All-Metal Aromatic Trinuclear Complexes and Carboxylic Acids

The distinct reactivity of 1,6-enynes in the presence of a trinuclear metal complex activated by a carboxylic acid is presented. The triplatinum catalyst enables the cyclization of the substrate and subsequent incorporation of a nucleophile in the final product. In contrast, sequential cyclization/double bond shift occurs under analogous conditions in the presence of the corresponding tripalladium complex.

Hydroxy- and Alkoxycyclizations of Enynes Catalyzed by Platinum(II) Chloride

The cyclization of 1-en-6-ynes catalyzed by PtCl2 in the presence of water or alcohols affords five or six-membered ring carbocycles containing hydroxy or alkoxy functional groups in high yields. The alkoxycyclizations can also be performed wit

(Alkylthio)alkynes as addends in the Co(0) catalyzed intramolecular pauson-khand reaction. Substituent driven enhancements of annulation efficiency and stereoselectivity

Compared to terminal alkynes, (methylthio)alkynes are generally superior substrates for the thermally promoted, Co2(CO)8 catalyzed Pauson-Khand reaction of enynes and allenynes, providing enones in higher yields and with enhanced diastereoselectivity. Improvements in yield dependent upon the use of 2,2,2-trifluoroethanol as co-solvent and an apparent preference for endo selectivity with (ethoxy)alkynes are also disclosed.