293313-58-3

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 70-55-3 toluene-4-sulfonamide 
• 18303-04-3 N-[(tert-butoxy)carbonyl]-4-methylbenzenesulfonamide 
• 2028-63-9 but-3-yn-2-ol 

Downstream Products

• 1289257-32-4 C₁₇H₁₉NO₃S 
• 491879-61-9 4-methyl-N-(1-methylprop-2-ynyl)-benzenesulfonamide 
• 293313-59-4 N-2-(Pent-3-ynyl)-4-methylbenzenesulfonamide 

Relevant academic research and scientific papers

Solid form of heteroaryl-fused tetrahydropyridine compound and preparation method of heteroaryl-fused tetrahydropyridine compound

The present application discloses a solid form of a heteroaryl-fused tetrahydropyridine compound of a formula (I) and a preparation method thereof. The solid form comprises a crystal A, a crystal B, acrystal C and an amorphous form, wherein the crystal B has good physicochemical stability.

Annelated Cyclobutanes by Fe-Catalyzed Cycloisomerization of Enyne Acetates

Cationic Fe complexes of the general type [(Ph3P)2Fe(CO)(NO)]X (X=BF4, BArF4) catalyze the redox-neutral cycloisomerization of 1,6- and 1,7-enyneacetates to afford bicyclic cyclobutanes under mild conditions in good yields and diastereoselectivities.

Developing a diastereoselective intramolecular [4 + 3] cycloaddition of nitrogen-stabilized oxyallyl cations derived from N-sulfonyl-substituted allenamides

Efforts toward achieving a practical and diastereoselective intramolecular [4 + 3] cycloaddition of nitrogen-stabilized oxyallyl cations with tethered dienes are described. Epoxidation of N-sulfonyl substituted allenamides with dimethyldioxirane (DMDO) generates nitrogen-stabilized oxyallyl cations that readily undergo stereoselective [4 + 3] cycloaddition with dienes. Selectivity is found to depend on the tethering length as well as the stability of the oxyallyl cation intermediate, whether generated from N-carbamoyl- or N-sulfonyl-substituted allenamides. The use of chiral N-sulfonyl-substituted allenamides provided minimal diastereoselectivity in the cycloaddition, while high diastereoselectivity can be achieved with a stereocenter present on the tether. These studies provide further support for the synthetic utility of allenamides.

(Alkylthio)alkynes as addends in the Co(0) catalyzed intramolecular pauson-khand reaction. Substituent driven enhancements of annulation efficiency and stereoselectivity

Compared to terminal alkynes, (methylthio)alkynes are generally superior substrates for the thermally promoted, Co2(CO)8 catalyzed Pauson-Khand reaction of enynes and allenynes, providing enones in higher yields and with enhanced diastereoselectivity. Improvements in yield dependent upon the use of 2,2,2-trifluoroethanol as co-solvent and an apparent preference for endo selectivity with (ethoxy)alkynes are also disclosed.