29334-18-7

Usage

Uses

Used in Organic Synthesis:
Benzenemethanol,4-bromo-a-(4-bromophenyl)is used as a building block in organic synthesis for the creation of various chemical compounds. Its unique structure and reactivity allow for the formation of new molecules with potential applications in different industries.
Used in Pharmaceutical Research:
In the pharmaceutical industry, Benzenemethanol,4-bromo-a-(4-bromophenyl)is utilized as a key intermediate in the development of new drugs. Its chemical properties enable the synthesis of pharmaceuticals with specific therapeutic effects.
Used in Agrochemical Production:
Benzenemethanol,4-bromo-a-(4-bromophenyl)also serves as a precursor in the production of agrochemicals, contributing to the development of effective pesticides and other agricultural products.
Used in Material Development:
Benzenemethanol,4-bromo-a-(4-bromophenyl)has potential applications in the development of new materials, such as polymers and coatings, due to its chemical properties and reactivity.
Used as a Reagent in Chemical Reactions:
Benzenemethanol,4-bromo-a-(4-bromophenyl)can be employed as a reagent in various chemical reactions, facilitating the synthesis of desired products and improving the efficiency of the reaction process.
It is crucial to handle Benzenemethanol,4-bromo-a-(4-bromophenyl)with care, as it may pose health and environmental hazards if not properly managed. Proper safety measures and disposal methods should be followed to minimize any potential risks associated with Benzenemethanol,4-bromo-a-(4-bromophenyl)-.

InChI:InChI=1/C13H10Br2O/c14-11-5-1-9(2-6-11)13(16)10-3-7-12(15)8-4-10/h1-8,13,16H

Upstream product

• 3988-03-2 bis(4-bromophenyl)methanone 
• 18066-91-6 4,4'-(bromomethylene)bis(bromobenzene) 
• 22480-64-4 4-bromophenyllithium 
• 1122-91-4 4-bromo-benzaldehyde 
• 117863-98-6 tetrakis-(4-bromo-phenyl)-[1,3]dioxolan-2-one 
• 106-37-6 1.4-dibromobenzene 
• 101-81-5 Diphenylmethane 
• 18620-02-5 (4-bromophenyl)magnesium bromide 
• 19226-36-9 3-phenyl-5H-1,4,2-dioxazol-5-one 
• 1941-86-2 bis(4-bromophenyl)methane 
• 64-17-5 ethanol 

Downstream Products

• 91-01-0 1,1-Diphenylmethanol 
• 3988-03-2 bis(4-bromophenyl)methanone 
• 21771-79-9 bis-(4-bromo-phenyl)-acetic acid 
• 871250-43-0 bis-(4'-trifluoromethylbiphenyl-4-yl)methanol 
• 1555554-82-9 2-((bis(4-bromophenyl)methyl)thio)-N-propylacetamide 
• 1555554-89-6 2-((bis(4-bromophenyl)methyl)thio)-N-(cyclopropylmethyl)acetamide 
• 1555554-94-3 2-((bis(4-bromophenyl)methyl)thio)-N-butylacetamide 
• 1555555-03-7 2-((bis(4-bromophenyl)methyl)thio)-N-(4-phenylbutyl)acetamide 
• 1555555-37-7 N-(2-((bis(4-bromophenyl)methyl)thio)ethyl)-3-phenylpropan-1-amine 
• 1555555-49-1 N-(2-((bis(4-bromophenyl)methyl)sulfinyl)ethyl)-3-phenylpropan-1-amine 
• 1555555-65-1 N-(2-((bis(4-bromophenyl)methyl)thio)ethyl)-3-phenylpropan-1-amine oxalate 
• 1555555-76-4 N-(2-((bis(4-bromophenyl)methyl)sulfinyl)ethyl)-3-phenylpropan-1-amine oxalate 
• 1555555-23-1 2-((bis(4-bromophenyl)methyl)thio)ethan-1-amine hydrochloride 
• 1253944-29-4 2-((bis(4-bromophenyl)methyl)thio)-N-methylacetamide 

Relevant academic research and scientific papers

Reduction over Condensation of Carbonyl Compounds through a Transient Hemiaminal Intermediate Using Hydrazine

Reduction of carbonyl moieties to the corresponding alcohol using simply hydrazine hydrate has been considerably unfeasible until now due to the well-known condensation reaction. However, herein, we report that using an excess of 20-fold equivalents, the reduction proceeds in excellent yields. 1H NMR study of the reaction and density functional theory (DFT) calculations indicate that the final fate of the hemiaminal intermediate is crucial to obtain the alcohol or the hydrazone.

Catalyst- And Silane-Controlled Enantioselective Hydrofunctionalization of Alkenes by Cobalt-Catalyzed Hydrogen Atom Transfer and Radical-Polar Crossover

The catalytic enantioselective synthesis of tetrahydrofurans, which are found in the structures of many biologically active natural products, via a transition-metal-catalyzed hydrogen atom transfer (TM-HAT) and radical-polar crossover (RPC) mechanism is described herein. Hydroalkoxylation of nonconjugated alkenes proceeded efficiently with excellent enantioselectivity (up to 94% ee) using a suitable chiral cobalt catalyst, N-fluoro-2,4,6-collidinium tetrafluoroborate, and diethylsilane. Surprisingly, the absolute configuration of the product was highly dependent on the steric hindrance of the silane. Slow addition of the silane, the dioxygen effect on the solvent, thermal dependence, and DFT calculation results supported the unprecedented scenario of two competing selective mechanisms. For the less-hindered diethylsilane, a high concentration of diffused carbon-centered radicals invoked diastereoenrichment of an alkylcobalt(III) intermediate by a radical chain reaction, which eventually determined the absolute configuration of the product. On the other hand, a more hindered silane resulted in less opportunity for a radical chain reaction, instead facilitating enantioselective kinetic resolution during the late-stage nucleophilic displacement of the alkylcobalt(IV) intermediate.

Trivalent Rare-Earth Metal Amide Complexes as Catalysts for the Hydrosilylation of Benzophenone Derivatives with HN(SiHMe2)2 by Amine-Exchange Reaction

The rare-earth metal complexes Ln(L1)[N(SiHMe2)2](thf) (Ln=La, Ce, Y; L1=N,N′′-bis(pentafluorophenyl)diethylenetriamine dianion) were synthesized by treating Ln[N(SiHMe2)2]3(thf)2 with L1H2. The lanthanum and cerium derivatives are active catalysts for the hydrosilylation of benzophenone derivatives with HN(SiHMe2)2. An amine-exchange reaction was revealed as a key step of the catalytic cycle, in which Ln?Si?H β-agostic interactions are proposed to promote insertion of the carbonyl moiety into the Si?H bond.

Methane-perylene diimide-based small molecule acceptors for high efficiency non-fullerene organic solar cells

We report perylene diimide (PDI) small molecules based on diphenylmethane, triphenylmethane, and tetraphenylmethane cores, named PM-PDI2, PM-PDI3 and PM-PDI4, respectively. The OSC performances of PM-PDI3 and PM-PDI4 are comparable. The PM-PDI3 based device with PDBT-T1 as the donor achieved a highest power conversion efficiency (PCE) of 7.58% along with a high open-circuit voltage (VOC) of 0.98 V, a short-circuit current density (JSC) of 11.02 mA cm-2 and a high fill factor (FF) of 69.9%, a 1.32 times boost in PCE with respect to the PM-PDI2 based control device (3.26%). The high photovoltaic performance of the PM-PDI3 based device can be attributed to its relatively high-lying LUMO level, complementary absorption spectra with the polymer donor material PDBT-T1, relatively favorable morphology and improved exciton dissociation and charge collection efficiency. A PCE of 7.58% is among the highest efficiency of phenyl-methane as core based non-fullerene organic solar cells. Overall, this work provides a new approach to enhance the performance of non-fullerene acceptors.

Immobilized palladium nanoparticles on a cyclodextrin-polyurethane nanosponge (Pd-CD-PU-NS): An efficient catalyst for cyanation reaction in aqueous media

Immobilized palladium nanoparticles on a cyclodextrin-polyurethane nanosponge (Pd-CD-PU-NS) were found to be an efficient heterogeneous catalyst in the cyanation reaction of aryl halides in aqueous media. This catalyst system is containing palladium nanoparticles with a size of ～7 nm. Moreover, the CD-PU-NS support formed microsphere-shaped structures with a size of ～100–200 nm. The TEM images show that Pd nanoparticles were formed in near spherical shape morphology and were immobilized in the structure of the CD-PU-NS support. Under our optimized reaction conditions, aryl cyanides were obtained in high yields in the presence of the Pd-CD-PU-NS catalyst. Our results demonstrated that the Pd-CD-PU-NS catalyst is highly effective in the cyanation reaction in aqueous media. Furthermore, the catalyst could be simply extracted from the reaction mixture, providing an efficient methodology for the synthesis of aryl cyanides. The Pd-CD-PU-NS catalyst could be recycled four times with almost consistent catalytic efficiency.

Hole transport-material based on ether structure, and preparation method and application thereof

The invention discloses a novel hole-transport material, and a preparation method and application thereof. The hole-transport material uses bis(diphenylmethane) connected with oxygen or sulfur as a core and diphenylamine substituted by an alkoxy group or

AlCl3 catalyzed coupling of: N-benzylic sulfonamides with 2-substituted cyanoacetates through carbon-nitrogen bond cleavage

A new cross-coupling reaction of N-benzylic sulfonamides with 2-substituted cyanoacetates for the synthesis of 2-substituted benzylbenzene was reported. In the presence of AlCl3, a broad range of N-benzylic sulfonamides reacted smoothly with 2-substituted cyanoacetates to afford structurally diverse benzylbenzenes in moderate to excellent yields. The conversion could be enlarged to gram-scale efficiently. The practicability of this approach was further manifested in the synthesis of a related bioactive agent with high anti-inflammatory activity.

Synthesis and biological evaluation of aryloxyacetamide derivatives as neuroprotective agents

A series of new aryloxyacetamide derivatives 10a-s and 14a-m are designed and synthesized. Their protective activities against the glutamate-induced cell death were investigated in differentiated rat pheochromocytoma cells (PC12 cells). Most compounds exhibited neuroprotective effects, especially for 10m, 10r, 14b and 14c, which showed potential protection of PC12 cells at three doses (0.1, 1.0, 10 μM). MTT assay, Hoechst 33342/PI double staining, and high content screening (HCS) revealed that pretreatment of the cells with 10m, 10r, 14b and 14c has significantly decreased the extent of cell apoptosis in a dose-dependent manner. The results of western blot analysis demonstrated these compounds suppressed apoptosis of glutamate-induced PC12 cells via caspase-3 pathway. These compounds can be lead compounds for further discovery of neuroprotective agents for treating cerebral ischemic stroke. Basic structure-activity relationships are also presented.

Co(III)-Catalyzed Synthesis of Quinazolines via C-H Activation of N-Sulfinylimines and Benzimidates

C-H activation of arenes has been established as an important strategy for heterocycle synthesis via annulations between arenes and unsaturated coupling partners. However, nitriles failed to act as such a coupling partner. Dioxazolones have been employed as a synthon of nitriles, and subsequent coupling with arenes such as N-sulfinylimines and benzimidates bearing a functionalizable directing group provided facile access to two classes of quinazolines under Co(III)-catalysis.

Elucidation of structural elements for selectivity across monoamine transporters: Novel 2-[(diphenylmethyl)sulfinyl]acetamide (modafinil) analogues

2-[(Diphenylmethyl)sulfinyl]acetamide (modafinil, (±)-1) is a unique dopamine uptake inhibitor that binds the dopamine transporter (DAT) differently than cocaine and may have potential for the treatment of psychostimulant abuse. To further investigate structural requirements for this divergent binding mode, novel thio- and sulfinylacetamide and ethanamine analogues of (±)-1 were synthesized wherein (1) the diphenyl rings were substituted with methyl, trifluoromethyl, and halogen substituents and (2) substituents were added to the terminal amide/amine nitrogen. Halogen substitution of the diphenyl rings of (±)-1 gave several amide analogues with improved binding affinity for DAT and robust selectivity over the serotonin transporter (SERT), whereas affinity improved at SERT over DAT for the p-halo-substituted amine analogues. Molecular docking studies, using a subset of analogues with DAT and SERT homology models, and functional data obtained with DAT (A480T) and SERT (T497A) mutants defined a role for TM10 in the substrate/inhibitor S1 binding sites of DAT and SERT.