29334-67-6Relevant academic research and scientific papers
Synthesis, crystal structures and properties of two copper (II) complexes with pyridazine derivative ligand
Li, Xiu-Rong,Zhang, Zhi-Hui,Liu, Xiu-Feng,Gao, Hong,Zhang, Xiang-Nan,Fan, Zhi-Jin
, p. 781 - 786 (2008)
Two new complexes, [Cu(L)2(CH3OH)]·(ClO 4)2 (1) and [Cu(L)2(H2O)] ·(NO3)2 (2), have been synthesized and their crystal structures have been determined by X-ray analysis, where L = 3-(3,5-bimethylpyrazole-yl)-6-chloro-pyridazine]. The complex 1 crystallizes in the monoclinic, space group C2/c, and the coordination configuration of copper (II) is better described as trigonal pyramidal geometry with four N atoms from L and one O methanol . The coordination configuration of 2 is quite similar to that of 1 except Owater instead of O methanol . The intermolecular hydrogen bonds link the repeat units and extend the molecules to multinuclear structures in both compounds. The spectral properties of the title compounds have been studied and discussed. Furthermore, the antibacterial activities of the title compounds have been detected, the results indicate that the ligands and two copper(II) complexes exhibit certain fungicidal activities again several bacteria.
Synthesis of Some Novel 2,6-Disubstituted Pyridazin-3(2H)-one Derivatives as Analgesic, Anti-Inflammatory, and Non-Ulcerogenic Agents
Ibrahim, Tamer H.,Loksha, Yasser M.,Elshihawy, Hosam A.,Khodeer, Dina M.,Said, Mohamed M.
, (2017/09/05)
Some novel 2,6-disubstituted pyridazine-3(2H)-one derivatives were synthesized and evaluated for in vitro cyclooxygenase-2 (COX-2) inhibitory efficacy. Compounds 2-{[3-(2-methylphenoxy)-6-oxopyridazin-1(6H)-yl]methyl}-1H-isoindole-1,3(2H)-dione (5a), 2-pr
Synthesis, antibacterial and antioxidant properties of pyrazolylpyridazines
Ather, Abdul Qayuum,Chaudhry, Faryal,Khan, Muhammad Naeem,Bueno, Eliana Aparecida Silicz,Khan, Misbahul Ain,Aslam, Noreen,Khan, Khalid M.,Athar, Muhammad Makshoof,Munawar, Munawar Ali,Ashraf, Muhammad,Ejaz, Syeda Abida
, p. 7743 - 7748 (2013/09/23)
A number of 6-chloro-3-(pyrazol-1′-yl) pyridazines were prepared from 3,6-dichloropyridazine via either reaction with hydrazine followed I by reaction with appropriate reagents to develop the pyrazole or through a nucleophilic reaction with a pyrazole. So
New pyridazine-bridged NHC/pyrazole ligands and their sequential silver(I) coordination
Wimberg, Jan,Scheele, Ulrich J.,Dechert, Sebastian,Meyer, Franc
scheme or table, p. 3340 - 3348 (2011/09/30)
A family of new pyridazine-bridged NHC/pyrazole ligand precursors HL 1-5 were prepared and fully characterized including analysis by XRD {HL1 = 3-[3-(2,6-diisopropylphenyl)-3H-imidazolium-1-yl]-6-(3- pyridin-2-yl-pyrazol-1-yl)-pyrida
Synthesis of amide derivatives of [6-(3,5-dimethylpyrazol-1-yl)-3(2H)- pyridazinone-2-yl]acetic acid and their analgesic and anti-inflammatory properties
Banoglu, Erden,Akoglu, Cagla,Uenlue, Serdar,Erguen, Burcu Caliskan,Kuepeli, Esra,Yesilada, Erdem,Sahin, M. Fethi
, p. 520 - 527 (2007/10/03)
A series of structurally different amide derivatives of [6-(3,5-dimethylpyrazol-1-yl)-3(2H)-pyridazinone-2-yl] acetic acid were prepared and tested for their analgesic and anti-inflammatory activity in vivo by using p-benzoquinone-induced writhing test an
Intramolecular hydrogen bonding between 2-cyanoguanidine and 3-chloro-6-(pyrazol-1-yl)pyridazines in copper(II) complexes
Blake, Alexander J.,Hubberstey, Peter,Li, Wan-Sheung,Russell, Claire E.,Smith, Beverley J.,Wraith, Louise D.
, p. 647 - 655 (2007/10/03)
Treatment of copper(II) salts with 3-chloro-6-(pyrazol-1-yl)pyridazine (cppd)-2-cyanoguanidine (enge) mixtures yielded [Cu(cppd)2(H2O)2[NO3]2, [Cu(cppd)(cnge)2(H2O)(FBF3)][BF4], Cu(cppd)2Cl2·2H2O and Cu(cppd)2Br2· 2H2O. The corresponding 3-chloro-6-(3,5-dimethylpyrazol-1-yl)pyridazine (cmppd) systems gave Cu(cmppd)-(cnge)2(NO3)2·6H2O, [Cu(cmppd)2(cnge)][BF4]2, [Cu(cmppd)(cnge)Cl2]·H2O and Cu(cmppd)(cnge)Br2·H2O. Four of the complexes have been structurally characterised. Whereas the copper atoms in [Cu(cppd)2(H2O)2][NO3]2 and [Cu(cppd)(cnge)2(H2O)(FBF3)][BF4] have tetragonally elongated distorted octahedral geometry, those in [Cu(cmppd)2(cnge)][BF4]2 and [Cu(cmppd)(cnge)Cl2]·H2O adopt trigonal-bipyramidal geometries. The centrosymmetric [Cu(cppd)2(H2O)2]2+ cation comprises two equatorial bidentate chelating cppd ligands and two axial water molecules while [Cu(cppd(cnge)2(H2O)(FBF3)]+ comprises one cppd and two monodentate cnge molecules as equatorial ligands and one water molecule and one BF4- anion as axial ligands. In the [Cu(cmppd)(cnge)Cl2] molecule the chlorine atoms occupy equatorial sites, the cnge an axial position and the cmppd ligand straddles equatorial and axial sites, while in the [Cu(cmppd)2(cnge)]2+ cation the cnge ligand is located equatorially and the two cmppd ligands straddle equatorial and axial sites. Preliminary structural data for Cu(cppd)2Br2·2H2O are consistent with a centrosymmetric tetragonally elongated octahedral copper atom similar to that in [Cu(cppd)2-(H2O)2][NO3]2. Comparable IR and UV/VIS data were obtained for Cu(cmppd)(cnge)2(NO3)2·6H2O and [Cu(cppd)(cnge)2(H2O)(FBF3)][BF4] and for Cu(cmppd)(cnge)Br2·H2O and [Cu(cmppd)(cnge)Cl2]·H2O, suggesting similar molecular structures. Intramolecular N-H ... N hydrogen bonds occur between enge amino groups and pyridazine non-ligating nitrogens in the mixed-ligand complexes [Cu(cppd)(cnge)2(H2O)(FBF3)][BF4] and [Cu(cmppd)(cnge)Cl2]·H2O but not [Cu(cmppd)2(cnge)][BF4]2. That in [Cu(cppd)(cnge)2(H2O)(FBF3)][BF4] differentiates between the two cnge ligands, their different roles being confirmed by the presence of two diagnostic vasym(NCN) doublets in its IR spectrum.
