2935-32-2

Basic information

• Product Name: 18BETA(H)-OLEAN-12-ENE-3,11-DIONE
• Synonyms: 18BETA(H)-OLEAN-12-ENE-3,11-DIONE;3,11-Dioxo-β-amyrene;5α-Oleana-12-ene-3,11-dione;Olean-12-ene-3,11-dione;3,11-Dioxoolean-12-ene
• CAS NO: 2935-32-2
• Molecular Formula: C₃₀H₄₆O₂
• Molecular Weight: 438.69
• Mol File: 2935-32-2.mol

Chemical Properties

• Melting Point: 228-231 °C
• Boiling Point: 521.9 °C at 760 mmHg
• Flash Point: 192.3 °C
• Appearance: /
• Density: 1.05 g/cm³
• CAS DataBase Reference: 18BETA(H)-OLEAN-12-ENE-3,11-DIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 18BETA(H)-OLEAN-12-ENE-3,11-DIONE(2935-32-2)
• EPA Substance Registry System: 18BETA(H)-OLEAN-12-ENE-3,11-DIONE(2935-32-2)

Safety Data

• Hazardous Substances Data: 2935-32-2(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
18BETA(H)-OLEAN-12-ENE-3,11-DIONE is used as a therapeutic agent for its anti-inflammatory properties, helping to reduce inflammation and alleviate symptoms associated with inflammatory conditions.
18BETA(H)-OLEAN-12-ENE-3,11-DIONE is used as a therapeutic agent for its antidiabetic properties, aiding in the regulation of blood sugar levels and improving insulin sensitivity in individuals with diabetes.
18BETA(H)-OLEAN-12-ENE-3,11-DIONE is used as an anti-cancer agent, exhibiting inhibitory effects on tumor growth and progression, and potentially enhancing the efficacy of conventional chemotherapeutic drugs.
Used in Traditional Medicine:
18BETA(H)-OLEAN-12-ENE-3,11-DIONE is used as a healing agent for its various biological activities, including its anti-inflammatory, antidiabetic, and anti-cancer properties, to treat a range of health conditions and promote overall well-being.

Upstream product

• 559-70-6 beta-amyrin 
• 118916-58-8 β-amyrone 
• 64-19-7 acetic acid 

Relevant articles and documents

Chemical constituents of Psychotria nemorosa gardner and antinociceptive activity

Through dereplication strategies using gas chromatography-mass spectrometry (GC-MS) and ultra fast liquid chromatography-tandem mass spectrometry (UFLC-MS/MS), the ethanol extract from Psycotria nemorosa leaves (Rubiaceae) showed to be composed of: cinnamic acid, dihydroactinidiolide, 4-hydroxy-β-ionone, phytol, isophytol, 4,8,12,16-tetramethylheptadecan- 4-olide, lupeol, a mixture of α/β-amyrin, the keto and acetylated derivatives, besides stigmast- 4-en-3-one, campesterol, stigmasterol and γ-sitosterol by GC-MS. Likewise, by UFLC-MS/MS, the main compounds identified were: butin, resveratrol, rutin, kaempferol 7-O-β-D-glucopyranoside, deacetylasperuloside, epiloganin, hordenine, strictosidine, N-methyl-1,2,3,4-tetrahydro-β-carboline and N-formyl-tryptamine. The antinociceptive activity of the crude extract ant its fractions was reported.

Biomimetic oxidation of 3β-hydroxy-olean-12-ene and its acetoxy derivative with monooxygen donors catalyzed by 5,10,15,20-tetraarylporphyrinatoiron(III) chlorides in dichloromethane

The oxidation of 3β-hydroxy-olean-12-ene with monooxygen donors catalyzed by 5,10,15,20-tetraarylporphyrinatoiron(III) chlorides in dichloromethane gives 3β,11α-dihydroxy-olean-12-ene, 3-oxo-olean-12-ene, 3,11-dioxo-olean-12-ene and 3β-hydroxy-olean-9(11),12-diene whereas the oxidation of 3β-acetoxy-olean-12-ene under similar conditions gives 11(-hydroxy-3β-acetoxy-olean-12-ene, 11-oxo-3β-acetoxy-olean-12-ene and 3β-acetoxy-olean-9(11),12-diene in moderate yields.

Functionalisation of Saturated Hydrocarbons. Part 6. Selective Oxidation of Steroids and Related Compounds

The oxidation of a series of steroids by the Gif system gives, almost without exception, the 20-ketone as major isolated product.The side-chain cleavage is made more selective by modification of rings A or B.The oxidation of oleana-1,12-diene-3,11-dione has also been studied and the two principal products have been identified.