29366-73-2

Basic information

• Product Name: 2,4-Diamino-6-(4-nitrophenyl)-1,3,5-triazine
• Synonyms: 2,4-Diamino-6-(4-nitrophenyl)-1,3,5-triazine;6-(4-Nitrophenyl)-1,3,5-triazine-2,4-diamine;1,3,5-Triazine-2,4-diaMine, 6-(4-nitrophenyl)-
• CAS NO: 29366-73-2
• Molecular Formula: C₉H₈N₆O₂
• Molecular Weight: 232.1988
• Mol File: 29366-73-2.mol
• Article Data: 7

Chemical Properties

• Melting Point: 330-331 °C
• Boiling Point: 588.7°Cat760mmHg
• Flash Point: 309.8°C
• Appearance: /
• Density: 1.539g/cm³
• Vapor Pressure: 7.78E-14mmHg at 25°C
• Refractive Index: 1.729
• PKA: 3.85±0.10(Predicted)
• CAS DataBase Reference: 2,4-Diamino-6-(4-nitrophenyl)-1,3,5-triazine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-Diamino-6-(4-nitrophenyl)-1,3,5-triazine(29366-73-2)
• EPA Substance Registry System: 2,4-Diamino-6-(4-nitrophenyl)-1,3,5-triazine(29366-73-2)

Safety Data

• Hazardous Substances Data: 29366-73-2(Hazardous Substances Data)

Usage

General Description

2,4-Diamino-6-(4-nitrophenyl)-1,3,5-triazine is a chemical compound that belongs to the group of triazine derivatives. It is known for its potential use as a herbicide, specifically for controlling broadleaf weeds in crops such as wheat, maize, and sorghum. The compound contains two amino groups and a nitrophenyl group attached to the triazine ring, giving it its unique chemical structure. 2,4-Diamino-6-(4-nitrophenyl)-1,3,5-triazine is also used in various research and pharmaceutical applications due to its reactivity and potential biological activity. However, it is important to note that this compound should be handled and used with caution due to its potential toxicity and environmental impact.

InChI:InChI=1/C9H8N6O2/c10-8-12-7(13-9(11)14-8)5-1-3-6(4-2-5)15(16)17/h1-4H,(H4,10,11,12,13,14)

Upstream product

• 555-16-8 4-nitrobenzaldehdye 
• 127099-85-8 N-Cyanoguanidine 
• 619-72-7 4-nitrobenzonitrile 

Downstream Products

• 186834-91-3 N-[4-Isobutyrylamino-6-(4-nitro-phenyl)-[1,3,5]triazin-2-yl]-isobutyramide 
• 15074-26-7 2,4-Diamino-6-(4-aminophenyl)-1,3,5-triazine 
• 1197159-91-3 4-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)aniline 
• 1197160-78-3 PKI-587 

Relevant articles and documents

New and Practical Synthesis of Gedatolisib

A new, practical, and convergent synthetic route of gedatolisib, an antitumor agent, is developed on a hectogram scale which avoids the Pd coupling method. The key step is adopting 6-(4-nitrophenyl)-1,3,5-triazine-2,4-diamine and 2,2′-dichlorodiethyl ether to prepare the key 4,4′-(6-(4-nitrophenyl)-1,3,5-triazine-2,4-diyl)dimorpholine in 77% yield and 98.8% purity. Gedatolisib is obtained in 48.6% yield over five simple steps and 99.3% purity (HPLC). Purification methods of the intermediates and the final product involved in the route are given.

Microwave-assisted one-pot tandem reactions for direct conversion of primary alcohols and aldehydes to triazines and tetrazoles in aqueous media

(Chemical Equation Presented) A series of primary alcohols and aldehydes were treated with iodine in ammonia water under microwave irradiation to give the intermediate nitriles, which without isolation underwent [2 + 3] cycloadditions with dicyandiamide and sodium azide to afford high yields of the corresponding triazines and tetrazoles, including the α-amino- and dipeptidyl tetrazoles in high optical purity.

Microwave-assisted clean synthesis of 6-aryl-2,4-diamino-1,3,5-triazines in [bmim][PF6]

An efficient and green approach was developed to prepare 6-aryl-2,4-diamino-1,3,5-triazines from corresponding arylnitriles and dicyanodiamide in ionic liquid [bmim][PF6] under computer-controlled microwave irradiation. Particularly valuable features of this method included the short reaction time, good yield, convenient operation and eco-friendly solvent.