29367-22-4Relevant academic research and scientific papers
Synthesis and antibacterial activity of some novel bis-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazoles and bis-4-thiazolidinone derivatives from terephthalic dihydrazide
Palekar, Vikrant S.,Damle, Amey J.,Shukla
experimental part, p. 5112 - 5116 (2010/02/27)
A novel series of 1,4-bis(6-(substituted phenyl)-[1,2,4]-triazolo[3,4-b]-1,3,4-thiadiazoles (5a-b) and 4-bis(substituted phenyl)-4-thiazolidinone derivatives (7a-c) have been synthesized from terephthalic dihydrazide (1) through multistep reaction sequence. 1,4-Bis(5-aryl-1,3,4-oxadiazole-2yl) benzene derivatives (2a-f) and bis-substituted terephthalohydrazide (6a-e) were also synthesized from terephthalic dihydrazide by cyclization with various aromatic acids and aldehydes. Terephthalic dihydrazide (1) was obtained from poly(ethylene terephthalate) waste from reaction with hydrazine hydrate in good yield (86%). All the synthesized compounds were screened for their antibacterial activities against various bacteria and fungi strains. Several of these compounds showed potential antibacterial activity.
Synthesis and antibacterial activities of bis-1,3, 4-oxadiazoline derivatives
Li, De-Jiang,Dan, Fei-Jun,Fu, He-Qing
scheme or table, p. 465 - 468 (2010/03/04)
Dimethyl terephthalate (1) was reacted with 80% hydrazine hydrate in refluxing methanol for 12 h to afford terephthalate dihydrazide (2). Condensation of 2 with aromatic aldehydes afforded corresponding hydrazones 3a-3j. Cyclization of 3a-3j with acetic anhydride in refluxing for 4-5 h afforded bis-1,3,4-oxadiazoline derivatives(4a-4j). The structures of 4a-4j were characterized by elementary analyses, IR, 1H NMR, and MS spectroscopy. The preliminary antibacterial tests showed that most of them were effective against S.aureus.
Controlled release of volatile aldehydes and ketones from dynamic mixtures generated by reversible hydrazone formation
Levrand, Barbara,Fieber, Wolfgang,Lehn, Jean-Marie,Herrmann, Andreas
, p. 2281 - 2314 (2008/03/29)
Delivery systems generated by reversible hydrazone formation from hydrazine derivatives (see Fig. 1) and carbonyl compounds in H2O efficiently increase the long-lastingness of volatile aldehydes and ketones (R 1R2C=O) in various perfumery applications. The hydrazones are usually obtained in an (E) configuration at the imine double bond (NHN=C) and, in the case of aliphatic acylhydrazones R′CO-NH-N=CR 1R2 (R′ = alkyl), as syn and anti conformers with respect to the amide bond (CO-NHN). An average free-energy barrier of ca. 78kJ/mol was determined for the amide-bond rotation by variable-temperature 1H-NMR measurements (Fig. 2). In the presence of H2O, the hydrazone formation is entirely reversible, reaching an equilibrium composed of the hydrazine derivative, the carbonyl compound, and the corresponding hydrazone. Kinetic measurements carried out by UV/VIS spectroscopy showed that the same equilibrium was reached for the formation and hydrolysis of the hydrazone. Rate constants are strongly pH-dependent and increase with decreasing pH (Table 1). The influence of the hydrazine structure on the rate constants is less pronounced than the pH effect, and the presence of surfactants reduces the rate of equilibration (Tables 1 and 3). The full reversibility of the hydrazone formation allows to prepare dynamic mixtures by simple addition of a hydrazine derivative to several carbonyl compounds. Dynamic headspace analysis on dry cotton showed that the presence of a hydrazine derivative significantly increased the headspace concentrations of the different carbonyl compounds as compared to the reference sample without hydrazine (Table 4). The release of the volatiles was found to be efficient for fragrances with high vapor pressures and low H2O solubility. Furthermore, a special long-lasting effect was obtained for the release of ketones. The simplicity of generating dynamic mixtures combined with the high efficiency for the release of volatiles makes these systems particularly interesting for practical applications and will certainly influence the development of delivery systems in other areas such as the pharmaceutical or agrochemical industry.
USE OF DYNAMIC MIXTURES FOR A CONTROLLED RELEASE OF FRAGRANCES
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Page/Page column 34-37, (2008/06/13)
The present invention relates to a delivery system in the form of a dynamic mixture obtained by reacting together, in the presence of water, at least one hydrazine derivative with at least one perfuming, flavoring, insect repellent or attractant, bactericide and/or fungicide aldehyde or ketone. The invention's mixture is capable of releasing in a controlled and prolonged manner said aldehyde or ketone in the surrounding environment. Furthermore, the present invention concerns also the use of said dynamic mixtures as perfuming ingredients as well as the perfuming compositions or perfumed articles comprising the invention's mixtures.
A SPECTRAL STUDY OF URANYL(VI) COMPLEXES OF HYDRAZIDES AND HYDRAZONES
Chandra, Ramesh,Kapoor, Ramesh N.
, p. 1125 - 1132 (2007/10/03)
Metal complexes of uranyl(VI) with nitrogen and oxygen containing bidentate and tridentate ligands, carbohydrazide (CHZ), 1,5-diphenylcarbazide (DPC), terephthalic acid hydrazide (TDH) and bis-benzaldehyde terephthalic hydrazone (BBTH) have been studied. The complexes of carbohydrazide and 1,5-diphenylcarbazide in 1:2 metal to ligand molar ratio, whereas TDH and BBTH complexes in 1:1 molar ratio have been synthesized. All the complexes have been characterized as seven-coorinated UO2(VI) systems, in which these ligands coordinate through carbonyl and terminal amino groups. All the complexes show bands in the region 830-840 and 910-920 cm-1, which are assigned to νsym. and νasym. UO2 vibrations.
