2937-80-6Relevant academic research and scientific papers
Synthesis of 2-(2',3'-Dihydroxypropyl)-5-amino-2H-1,2,4-thiadiazol-3-one and 3-(2',3'-Dihydroxypropyl)-5-amino-3H-1,3,4-thiadiazol-2-one
Parkanyi, Cyril,Yuan, Hui Liang,Cho, Nam Sook,Jaw, JIn-Hwa J.,Woodhouse, Tamar E.,Aung, Thomas L.
, p. 1331 - 1334 (2007/10/02)
The synthesis of two new acyclic nucleoside analogs, 2-(2',3'-dihydroxypropyl)-5-amino-2H-1,2,4-thiadiazol-3-one (1) and 3-(2',3'-dihydroxypropyl)-5-amino-3H-1,3,4-thiadiazol-2-one (2), is reported.The first compound, 1, was obtained by reaction of 3-chloro-1,2-propanediol with the sodium salt of 5-amino-2H-1,2,4-thiadiazol-3-one (3) in anhydrous dimethylformamide.Similarly, 5-amino-3H-1,3,4-thiadiazol-2-one (4) reacted with 3-chloro-1,2-propanediol to give 2.The thiadiazole 4 was prepared by condensation-cyclization of hydrazothiodicarbonamide (9).
