293729-56-3Relevant academic research and scientific papers
Synthesis of pyrazoles from 1-acylmethylene-3,3-dimethyl-1,3-dihydroisobenzofurans
Sos?nicki, Jacek G.
, p. 475 - 486 (2007/10/03)
1-Acylmethylene-3,3-dimethyl-1,3-dihydroisobenzofurans were found to be useful precursors for pyrazole synthesis. In the reaction with hydrazine monohydrate they yielded 3-(2-(α-hydroxyisopropyl)-phenyl) substituted NH-pyrazoles, whereas using alkyl-or arylhydrazine gave access to 5-(2-(α-hydroxyisopropyl)-phenyl) substituted NR-pyrazoles with good regioselectivity. Treatment with orthophosphoric acid led to C,N-fused and C,C-fused pyrazoles, respectively.
