293733-51-4

Upstream product

• 41806-40-0 1-methyl-1H-imidazole-5-carboxylic acid 
• 75-65-0 tert-butyl alcohol 

Relevant academic research and scientific papers

IMIDAZOPYRIDINONE COMPOUND

The present invention aims to provide a novel compound which has prolyl hydroxylase (PHDs) inhibitory effect and which is useful for the treatment of inflammatory bowel diseases such as ulcerative colitis and the like. The present invention relates to a imidazopyridinone compound represented by the following formula (I) or a pharmaceutically acceptable salt thereof. The compounds of the present invention or pharmaceutically acceptable salts thereof which have prolyl hydroxylase inhibitory effect and, are useful as agents for the treatment of inflammatory bowel diseases such as ulcerative colitis and the like. In an embodiment, the present invention relates to a method for treating an inflammatory bowel disease

(HETERO) ARYL IMIDAZOLONE COMPOUND

PROBLEM TO BE SOLVED: To provide a novel compound that has an inhibitory action on prolyl hydroxylases (PHDs), and is useful as a treatment agent for inflammatory bowel diseases such as ulcerative colitis. SOLUTION: The present disclosure provides a (hetero) aryl imidazolone compound represented by the formula (I) or a pharmacologically acceptable salt thereof (where m, u, p, q and r each denote a specific integer, E, G, Q and T each denote a specific group such as N or CH, W and Z each denote a specific ring, R1 and R3 each denote a specific group such as a halogen atom). SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

METHOD FOR PRODUCING IMIDAZOPYRIDINONE COMPOUND

PROBLEM TO BE SOLVED: To provide a novel production method of an imidazopyridinone compound useful as a treatment agent for inflammatory bowel diseases (IBDs). SOLUTION: The present disclosure provides a method for the synthesis of, for example, an imidazopyridinone compound shown below. The method includes a process of introducing a desired substituent into the 1st-position of 2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridine, having an N-protected 3-pyrrolidino group at the 3rd-position; then deprotecting a 3rd-position substituent; and further introducing a desired substituent into N of the pyrrolidino group. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

PHARMACEUTICAL COMPOSITION CONTAINING IMIDAZOPYRIDINONE COMPOUND

PROBLEM TO BE SOLVED: To provide a compound useful as a treatment agent for inflammatory bowel diseases such as ulcerative colitis, and a pharmaceutical composition containing the same. SOLUTION: The present disclosure provides a pharmaceutical composition containing an imidazopyridinone compound of the following formula (I) or a pharmacologically acceptable salt thereof. SELECTED DRAWING: None COPYRIGHT: (C)2021,JPOandINPIT

SUBSTITUTED SULPHONAMIDES FOR CONTROLLING ANIMAL PESTS

The present invention relates to the use of a compound of the general formula (I) in which M and D have the meanings given in the description for controlling animal pests.

Functionalization of 1-methyl-1H-imidazole-5-carboxylic acid at the C-2 position: Efficient syntheses of 2-substituted t-butyl 1-methyl-1H-imidazole- 5-carboxylates

A number of 2-substituted t-butyl 1-methyl-1H-imidazole-5-carboxylates, which can be readily converted to the corresponding acids, were efficiently prepared from t-butyl 2-bromo-1-methyl-1H-imidazole-5-carboxylate via bromine-lithium exchange or palladium-catalysed coupling.