29375-30-2

Basic information

• Product Name: L-Alanyl-L-proline tert-Butyl Ester
• Synonyms: L-Alanyl-L-proline tert-Butyl Ester;L-Alanyl-L-proline 1,1-DiMethylethyl Ester
• CAS NO: 29375-30-2
• Molecular Formula: C₁₂H₂₂N₂O₃
• Molecular Weight: 242.31468
• Product Categories: Amino Acids 13C, 2H, 15N;Amino Acids & Derivatives;Heterocycles;Amino Acids & Derivatives, Heterocycles
• Mol File: 29375-30-2.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 358.2 °C at 760 mmHg
• Flash Point: 170.4 °C
• Appearance: /
• Density: 1.107 g/cm³
• Vapor Pressure: 2.59E-05mmHg at 25°C
• Refractive Index: 1.498
• Solubility: Chloroform, Ethyl Acetate, Metrhanol
• CAS DataBase Reference: L-Alanyl-L-proline tert-Butyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: L-Alanyl-L-proline tert-Butyl Ester(29375-30-2)
• EPA Substance Registry System: L-Alanyl-L-proline tert-Butyl Ester(29375-30-2)

Safety Data

• Hazardous Substances Data: 29375-30-2(Hazardous Substances Data)

Usage

Chemical Properties

Light Green Solid

InChI:InChI=1/C12H22N2O3/c1-8(13)10(15)14-7-5-6-9(14)11(16)17-12(2,3)4/h8-9H,5-7,13H2,1-4H3/t8-,9-/m0/s1

Upstream product

• 21027-01-0 N-benzyloxycarbonyl-L-alanyl-L-proline 
• 115-11-7 isobutene 
• 540-88-5 acetic acid tert-butyl ester 
• 56-41-7 L-alanin 
• 2812-46-6 proline tert-butyl ester 
• 27544-35-0 Cbz-L-Ala-L-Pro-O^tBu 
• 97327-27-0 HO-(S)-mAla-Pro-OtBu 
• 97327-27-0 HO-(R,S)-mAla-Pro-OtBu 
• 64623-83-2 EtO-(R,S)-mAla-Pro-OtBu 
• 97342-97-7 H₂N-(S)-mAla-Pro-OtBu 
• 1142-20-7 N-Cbz-Ala 

Downstream Products

• 107389-07-1 (S)-1-[(S)-2-(3-Phenyl-propionylamino)-propionyl]-pyrrolidine-2-carboxylic acid tert-butyl ester 
• 107389-06-0 (S)-1-{(S)-2-[(E)-1-(Diethoxy-phosphoryl)-3-phenyl-propenylamino]-propionyl}-pyrrolidine-2-carboxylic acid tert-butyl ester 
• 107389-08-2 (S)-1-{(S)-2-[(R)-1-(Diethoxy-phosphoryl)-3-phenyl-propylamino]-propionyl}-pyrrolidine-2-carboxylic acid tert-butyl ester 
• 107389-08-2 (S)-1-{(S)-2-[(S)-1-(Diethoxy-phosphoryl)-3-phenyl-propylamino]-propionyl}-pyrrolidine-2-carboxylic acid tert-butyl ester 
• 113247-53-3 (S)-1-[(S)-2-((S)-3-tert-Butoxycarbonylamino-2-hydroxy-2-methyl-4-phenyl-butylamino)-propionyl]-pyrrolidine-2-carboxylic acid tert-butyl ester 
• 120292-59-3 N-<(R)-1-(ethoxycarbonyl)-3-phenylpropyl>-L-alaninyl-L-proline tert-butylester 
• 108428-39-3 N--L-alanyl>-L-proline tert butyl ester 
• 120008-53-9 N-<8-Amino-1(s)-carboxyoctyl>-L-alanyl-L-proline 
• 107389-09-3 (S)-1-[(S)-2-((S)-3-Phenyl-1-phosphono-propylamino)-propionyl]-pyrrolidine-2-carboxylic acid 
• 107389-09-3 (S)-1-[(S)-2-((R)-3-Phenyl-1-phosphono-propylamino)-propionyl]-pyrrolidine-2-carboxylic acid 
• 118554-04-4 (S)-1-((S)-2-{N'-[1-(4-Nitro-phenyl)-meth-(E)-ylidene]-hydrazino}-propionyl)-pyrrolidine-2-carboxylic acid tert-butyl ester 
• 76420-72-9 enalaprilate 
• 105441-32-5 (3S,5S)-N-(tetrahydro-2-oxo-5-phenyl-3-furanyl)-(S)-alanyl-(S)-proline 
• 105499-24-9 (3S,5R)-N-(tetrahydro-2-oxo-5-phenyl-3-furanyl)-(S)-alanyl-(S)-proline 

Relevant articles and documents

A General Stereocontrolled Synthesis of Opines through Asymmetric Pd-Catalyzed N-Allylation of Amino Acid Esters

A stereo-divergent synthesis of natural and unnatural opines in stereochemically pure form is based on the direct palladium-catalyzed N-allylation of α-amino acid esters (up to 97 % ee or 99 : 1 d.r.) using methyl (E)-2-penten-4-yl carbonate in the presence of only 1 mol% of a catalyst, prepared in-situ from the C2-symmetric diphosphine iPr-MediPhos and [Pd(allyl)Cl]2. Selected target compounds (incl. a derivative of the drug enalapril) were efficiently obtained from the N-allylated intermediates by oxidative cleavage (ozonolysis) of the allylic C=C bond under temporary N-Boc-protection.

BROAD SPECTRUM ANTIBIOTICS

Provided herein are antibacterial compounds, wherein the compounds in some embodiments have broad spectrum bioactivity. The compounds provided herein can in other embodiments overcome the resistance conferred by single amino acid mutations at defined posi

The synthesis of an aminophosphonic acid converting enzyme inhibitor

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