293758-75-5Relevant academic research and scientific papers
Novel inhibitors of DNA gyrase: 3D structure based biased needle screening, hit validation by biophysical methods, and 3D guided optimization. A promising alternative to random screening
Boehm, Hans-Joachim,Boehringer, Markus,Bur, Daniel,Gmuender, Hans,Huber, Walter,Klaus, Werner,Kostrewa, Dirk,Kuehne, Holger,Luebbers, Thomas,Meunier-Keller, Nathalie,Mueller, Francis
, p. 2664 - 2674 (2007/10/03)
Random screening provided no suitable lead structures in a search for novel inhibitors of the bacterial enzyme DNA gyrase. Therefore, an alternative approach had to be developed. Relying on the detailed 3D structural information of the targeted ATP bindin
