29376-76-9

Upstream product

• 1871-76-7 diphenylacetic acid chloride 
• 14987-96-3 N-(4-bromophenyl)triphenyliminophosphorane 
• 117-34-0 2,2-diphenylacetic acid 

Downstream Products

• 21355-10-2 (3-benzo[1,3]dioxol-5-yl-2,4,4-triphenyl-isoxazolidin-5-ylidene)-(4-bromo-phenyl)-amine 
• 121876-51-5 5-Benzhydryl-1-(4-bromo-phenyl)-4-trimethylsilanyl-1H-[1,2,3]triazole 
• 130716-10-8 2-Benzhydryl-4-benzhydrylidene-6-bromo-3-(4-bromo-phenyl)-3,4-dihydro-quinazoline 
• 130716-07-3 12-Benzhydrylidene-2,8-dibromo-6,6-diphenyl-6,12-dihydro-indolo[2,1-b]quinazoline 
• 78373-94-1 3-(4-bromophenyl)-2-diphenylmethyl-4(3H)-quinazolinone 
• 41563-48-8 (2,2-diphenylethene-1,1-diyl)bis(phenylsulfane) 
• 41563-38-6 N-(4-Bromo-phenyl)-2,2-diphenyl-thioacetimidic acid phenyl ester 
• 41563-46-6 N-(4-Bromo-phenyl)-2,2-diphenyl-thioacetimidic acid ethyl ester 
• 22251-31-6 1-(p-bromophenyl)-5-diphenylmethyl-1,2,3-triazole 
• 30301-30-5 (4-bromo-phenyl)-(2,4,4-triphenyl-[1,2]oxazetidin-3-ylidene)-amine 
• 21355-11-3 (4-bromo-phenyl)-[3-(4-methoxy-phenyl)-2,4,4-triphenyl-isoxazolidin-5-ylidene]-amine 
• 21355-12-4 (4-bromo-phenyl)-[3-(2,3-dimethoxy-phenyl)-2,4,4-triphenyl-isoxazolidin-5-ylidene]-amine 
• 21355-13-5 (2-benzyl-3,4,4-triphenyl-isoxazolidin-5-ylidene)-(4-bromo-phenyl)-amine 
• 30121-44-9 (4-bromo-phenyl)-[2-(4-nitro-phenyl)-4,4-diphenyl-[1,2]oxazetidin-3-ylidene]-amine 

Relevant academic research and scientific papers

Rh-Catalyzed annulations of: N -methoxybenzamides with ketenimines: Synthesis of 3-aminoisoindolinones and 3-diarylmethyleneisoindolinones with strong aggregation induced emission properties

Rhodium-catalyzed C-H activation/annulation reactions of ketenimines with N-methoxybenzamides furnished 3-aminoisoindolin-1-ones and 3-(diarylmethylene)isoindolin-1-ones. The synthesized 3-(diarylmethylene)isoindolin-1-ones exhibited aggregation induced emissions in aqueous tetrahydrofuran solution and strong green-yellow emissions in solids.

Preparation of 1,2,5-Trisubstituted 1H-Imidazoles from Ketenimines and Propargylic Amines by Silver-Catalyzed or Iodine-Promoted Electrophilic Cyclization Reaction of Alkynes

From readily available propargylic amines, 1,2,5-trisubstituted imidazoles are efficiently obtained through a cascade reaction catalyzed by AgOTf or promoted by molecular iodine. The AgOTf-catalyzed reaction involves nucleophilic addition of propargylic amine to ketenimine, a silver-catalyzed electrophilic cyclization reaction of alkyne, and a tautomerism/isomerism/metal-H exchange cascade. The iodine-mediated counterpart yields 5-formyl-1,2-disubtituted imidazoles, which presumably includes a cascade hydrolysis/oxidation reaction. Furthermore, the presented protocol can be scaled up and the resultant 1,2,5-trisubstituted imidazole can be converted into fused indeno[1,2-d]imidazole. 1,2,5-Trisubstituted imidazoles are efficiently prepared from readily available propargylic amines through a AgOTf-catalyzed or molecular iodine-promoted cascade reaction. The presented protocol can be scaled up and the resultant 1,2,5-trisubstituted imidazoles can be converted into fused indeno[1,2-d]imidazoles.