29397-20-4

Upstream product

• 941-55-9 4-toluenesulfonyl azide 
• 75-07-0 acetaldehyde 
• 109-89-7 diethylamine 
• 616-39-7 N,N-diethylnmethylamine 
• 617-84-5 N-formyldiethylamine 
• 70-55-3 toluene-4-sulfonamide 
• 98-59-9 p-toluenesulfonyl chloride 
• 3695-00-9 di(4-tosyl)amine 
• 236404-04-9 N-(2-benzene-2,2-dichloroethylidene)-4-methylbenzenesulfonamide 
• 121-44-8 triethylamine 
• 21849-40-1 dibromamine-T 
• 4444-68-2 N,N-diethylbutylamine 
• 5336-75-4 4-(diethylamino)butyronitrile 
• 623-47-2 propynoic acid ethyl ester 

Downstream Products

• 4917-56-0 N-formyl-N-tosylamide 

Relevant academic research and scientific papers

Visible-light enabled room-temperature dealkylative imidation of secondary and tertiary amines promoted by aerobic ruthenium catalysis

Employing sulfonyl azide as a nitrogen donor, a visible-light-enabled aerobic dealkylative imidation of tertiary and secondary amines involving C(sp3)-C(sp3) bond cleavage with moderate to excellent yields at room temperature is described. It has been demonstrated that this imidation could take place spontaneously upon visible-light irradiation, and could be facilitated considerably by a ruthenium photocatalyst and oxygen. An alternative mechanism to the previous aerobic photoredox pathway has also been proposed.

Rapid and efficient synthesis of formamidines in a catalyst-free and solvent-free system

An operationally rapid and efficient synthesis of N-sulfonyl formamidines that proceeds under mild conditions was achieved by reaction of a mixture of an amine, a sulfonyl azide, and a terminal ynone under catalyst-free and solvent-free conditions. Terminal ynones provide the C source to formamidines via complete cleavage of CC. This journal is

Catalyst-free one-pot, four-component approach for the synthesis of di- And tri-substituted: N -sulfonyl formamidines

A straightforward one-pot, multicomponent approach was developed to synthesize di- and tri-substituted N-sulfonyl formamidines from sulfonyl chlorides, NaN3, ethyl propiolate, and primary/secondary amines under mild conditions without catalysts or additives. Structural analysis of the di-substituted sulfonyl formamidines indicated formation of the E-syn/anti isomeric form. Tri-substituted analogues only formed E-isomers.

Preparation method of sulfonyl formamidine derivative

The invention relates to a preparation method of a sulfonyl formamidine derivative, which comprises the following step: reacting an amine compound with a terminal alkyne ketone compound and sulfonyl azide to obtain the sulfonyl formamidine derivative. The preparation method disclosed by the invention has the advantages of high product yield, high purity, high atom economy and the like, has good scientific research value and application prospect, provides a brand new route for preparation of the sulfonyl formamidine derivative, can play an important role in the fields of drug intermediates, pesticide intermediates and the like, reduces the production cost, and has good application value and potential in industry and scientific research.

Transition metal- And catalyst-free one-pot green method for the synthesis of: N -sulfonyl amidines via direct reaction of sulfonyl azides with amines

In this report, a green synthesis of N-sulfonyl amidines via the direct reaction of tertiary or secondary amines with sulfonyl azides is described. Transition metal- and catalyst-free conditions were used for the synthesis of biologically important N-sulfonyl amidines. Further studies showed that the reaction proceeded via in situ aerobic oxidation of amines under reflux conditions.

Visible-Light-Mediated Sulfonylimination of Tertiary Amines with Sulfonylazides Involving Csp3-Csp3 Bond Cleavage

Visible-light-induced cross-coupling of arylsulfonyl azides with tertiaryamines in the presence of Eosin Y at room temperature has been achieved. This transformation features alkyl C-C bond cleavage and provides a green approach to N-sulfonylamidines under mild conditions.

Photoinduced Cascade Reaction of Tertiary Amines with Sulfonyl Azides: Synthesis of Amidine Derivatives

A metal-free cascade reaction of tertiary amines with sulfonyl azides promoted by acridinium salts under blue light irradiation was developed and provided amidine derivatives in moderate to good yields. Enamine was generated from tertiary amine via single-electron transfer promoted by acridinium salts, and the following [3+2] cyclization with sulfonyl azide and CH2N2 release afforded the desired products. (Figure presented.).

Nitroacenaphthene as a New Photocatalyst for the Synthesis of Sulfonyl Amidines

A small molecule, namely nitroacenaphthene, is reported for the first time as a recyclable visible-light photocatalyst for the construction of the C=N bond from sulfonyl azides and amines. This scalable, site-selective protocol provides a convenient way to access various sulfonyl amidines under mild conditions. Two reaction pathways are proposed, according to different transformation patterns.

The C=C Bond Decomposition Initiated by Enamine-Azide Cycloaddition for Catalyst- and Additive-Free Synthesis of N-Sulfonyl Amidines

The chemo-selective synthesis of N-sulfonyl amidines is realized via the decomposition of the enamine C=C bond of enaminoesters through an in situ generated triazoline intermediate. Control experiments prove that the electron withdrawing ester group in the enamine component is crucial in inducing the chemo-selective formation of amidines. The method is featured with high efficiency and sustainability by employing pure water as medium without requiring any catalyst or additive.

Air-Induced One-Pot Synthesis of N-Sulfonylformamidines from Sulfonyl Chlorides, NaN3, and Tertiary/Secondary Amines

An efficient and practical one-pot strategy for the synthesis of N-sulfonylformamidines was developed by directly using easily available sulfonyl chlorides, sodium azide and tertiary/secondary amines in the presence of 5 mol-% CuBr2 under aerob