2941-17-5

Basic information

• Product Name: 3-bromo-2,2-dimethylpropanoyl chloride
• CAS NO: 2941-17-5
• Molecular Formula: C₅H₈BrClO
• Molecular Weight: 199.4734
• Mol File: 2941-17-5.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 182.1°C at 760 mmHg
• Flash Point: 63.9°C
• Density: 1.501g/cm³
• Vapor Pressure: 0.823mmHg at 25°C
• Refractive Index: 1.48
• CAS DataBase Reference: 3-bromo-2,2-dimethylpropanoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-bromo-2,2-dimethylpropanoyl chloride(2941-17-5)
• EPA Substance Registry System: 3-bromo-2,2-dimethylpropanoyl chloride(2941-17-5)

Safety Data

• Hazardous Substances Data: 2941-17-5(Hazardous Substances Data)

Upstream product

• 4835-90-9 3-Hydroxy-2,2-dimethylpropanoic acid 
• 2843-17-6 3-bromo-2,2-dimethylpropionic acid 

Downstream Products

• 69635-70-7 3-bromo-2,2-dimethyl-N-[4-(4-methyl-6-oxo-1,4,5,6-tetrahydro-pyridazin-3-yl)-phenyl]-propionamide 
• 4613-11-0 2,3-diphenylbutane 
• 23695-27-4 C₁₃H₁₅BrCl₂N₂O₃ 

Relevant articles and documents

NON-SYSTEMIC TGR5 AGONISTS

Compounds of structure (I), or a stereoisomer, tautomer, pharmaceutically acceptable salt or prodrug thereof, wherein R1, R2, R3, R4, R8, R9, R10, R11, R12, A1, A2, X, Y and Z are as defined herein. Uses of such compounds as TGR5 antagonists and for treatment of various indications, including Type II diabetes meletus are also provided.

Converting gem-dimethyl groups into cyclopropanes via Pd-catalyzed sequential C-H activation and radical cyclization

(Diagram presented) A novel route to the synthesis of cyclopropane derivatives is described. 1,1-Dimethyls in 2-(1,1-dimethylalkyl) dimethyloxazolines are first converted into 1,3-diiodide derivatives via Pd-catalyzed sequential C-H activation and then radically cyclized to provide 2-(1-alkylcylclopropyl)-dimethyloxazolines. The use of EtOAc as a solvent is crucial for the diiodination of the functionalized substrates.

1,5-DIAZABICYCLO-(3.3.0)-OCTANE-2,6-DIONES AND DERIVATIVES.

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