2843-17-6

Usage

Uses

Bromopivalic Acid is a useful reagent in amidation with sulfoximine.

Synthesis Reference(s)

Journal of the American Chemical Society, 77, p. 3016, 1955 DOI: 10.1021/ja01616a029

InChI:InChI=1/C5H9BrO2/c1-5(2,3-6)4(7)8/h3H2,1-2H3,(H,7,8)

Upstream product

• 4835-90-9 3-Hydroxy-2,2-dimethylpropanoic acid 
• 1955-45-9 pivalolactone 
• 40894-00-6 3-bromo-2,2-dimethyl-propan-1-ol 
• 10035-10-6 hydrogen bromide 
• 7789-69-7 phosphorus pentabromide 
• 75-98-9 Trimethylacetic acid 
• 126-30-7 2,2-Dimethyl-1,3-propanediol 

Downstream Products

• 2941-17-5 3-bromo-2,2-dimethylpropanoic acid chloride 
• 35040-68-7 2,2-dimethyl-3-mercaptopropanoic acid 
• 19036-43-2 aminopivalic acid 
• 7726-95-6 bromine 
• 369372-28-1 3-bromo-2,2-dimethyl-propionic acid 4-allyl-3-oxo-cyclohex-1-enyl ester 
• 50547-91-6 β-benzoylaminopivalic acid 
• 85606-80-0 2,2-dimethyl-3-(N'-phenyl-ureido)-propionic acid 
• 1159929-59-5 C₁₅H₂₀BrFN₂O 
• 1159929-53-9 3-bromo-1-(4-methylphenylpiperazin-1-yl)-2,2-dimethylpropan-1-one 
• 1159929-49-3 C₁₅H₂₀BrClN₂O 
• 59193-77-0 3-amino-2,2-dimethylpropionic acid ethyl ester 
• 30452-00-7 methyl (3-bromo-2,2-dimethyl) propionate 
• 1356116-77-2 C₁₃H₁₅F₃O₂S 
• 1356116-78-3 C₁₂H₁₃F₃O₄S 

Relevant academic research and scientific papers

Ligand-Enabled Pd(II)-Catalyzed Bromination and Iodination of C(sp3)-H Bonds

We herein report the palladium(II)-catalyzed bromination and iodination of a variety of α-hydrogen-containing carboxylic acid and amino acid-derived amides. These reactions are exclusively enabled by quinoline-type ligands. The halogenated products obtained in this reaction are highly versatile and rapidly undergo further diversification. Further, we report the first example of a free carboxylic acid-directed Pd(II)-catalyzed C(sp3)-H bromination, enabled by quinoline ligands.

TARGETING COMPOUNDS

The disclosure provides, at least in part, liver, intestine and/or kidney-targeting compounds and their use in treating liver, intestine and/or kidney disorders, such as non-alcoholic steatohepatitis, alcoholic steatohepatitis, hepatocellular carcinoma, liver cirrhosis, and hepatitis B; and/or chronic kidney disease, glomerular disease such as IGA nephropathy, lupus nephritis, or polycystic kidney disease. The compounds are contemplated to have activity against methionyl aminopeptidase 2.

Catalytic Bromination of Alkyl sp3C-H Bonds with KBr/Air under Visible Light

Alkyl sp3C-H bonds of cycloalkanes and functional branch/linear alkanes have been successfully brominated with KBr using air or O2 as an oxidant at room temperature to 40 °C. The reactions are carried out in the presence of catalytic NaNO2 in 37% HCl (aq)/solvent under visible light, combining aerobic oxidations and photochemical radical processes. For various alkane substrates, CF3CH2OH, CHCl3, or CH2Cl2 is employed as an organic solvent, respectively, to enhance the efficiency of bromination.

Preparation method of alkane brominated material

The invention relates to a preparation method of an alkane brominated material. The preparation method comprises the following steps: adding alkane, a bromine-containing compound or elemental bromine,a catalyst and acid into a solvent; adding the solvent into a light-transmission reaction container under air or oxygen atmosphere; sealing; performing stirring reaction under constant pressure and light illumination conditions; then analyzing a nuclear magnetic yield, and performing extraction, drying, filtration, distillation under reduced pressure and column separation to obtain the alkane brominated material. Compared with the prior art, the preparation method disclosed by the invention has the advantages that by using low-cost and safe bromic salt as a bromine source, the air as an oxidizing agent and a nitrogen-containing reagent as the catalyst, reaction is carried out under the conditions of constant temperature and constant pressure, so that energy conservation and economy are realized, and the preparation method is convenient and safe to operate and is environmentally friendly.

METHOD FOR THE PREPARATION OF OMEGA-AMINO-ALKANEAMIDES AND OMEGA-AMINO-ALKANETHIOAMIDES AS WELL AS INTERMEDIATES OF THIS METHOD

The present invention relates to method for the preparation of an ω-amino-alkane(thio)amide having the formula (3). Furthermore, novel intermediates and partial reaction steps of the claimed method are disclosed.

Hypolipidemic benzothiazepines

The invention is concerned with novel hypolipidemic compounds of formula (I), with processes and novel intermediates for their preparation, pharmaceutical compositions containing them and with their use in medicine, particularly in the prophylaxis and treatment of hyperlipidemic conditions, and associated diseases such as atherosclerosis. STR1

Organic Sonochemistry - some illustrative examples of a new fundamental approach

The sonochemical behaviour of several organic reactions, selected according to their mechanisms, has been examined. Their experimental evolution follows the prediction developed previously, that sonication promotes reactions proceeding through radical pathways.

Herbicidal 3-isoxazolidinones and hydroxamic acids

Novel 3-isoxazolidinone compounds and novel hydroxamic acid intermediates from which they are prepared exhibit herbicidal activity to grassy and broad-leaf plant species while leaving legumes, especially soybeans, unaffected. The preparation and herbicidal activity of the compounds is exemplified.