294173-05-0Relevant academic research and scientific papers
Synthesis and biological evaluation of 2'-carbamate-linked and 2'-carbonate-linked prodrugs of paclitaxel selective activation by the tumor-associated protease plasmin
De Groot,Van Berkom,Scheeren
, p. 3093 - 3102 (2007/10/03)
The nontoxic paclitaxel-2'-carbamate prodrugs 2-5 and paclitaxel-2'-carbonate prodrug 6 were synthesized and tested for activation by the tumor-associated enzyme plasmin. A generally applicable method for the synthesis of paclitaxel-2'-carbamates was deve
