88246-14-4

Upstream product

• 13139-17-8 N-(Benzyloxycarbonyloxy)succinimide 
• 79338-78-6 H-D-Val-Leu-Lys-OH 
• 501-53-1 benzyl chloroformate 
• 55790-11-9 Cbz-D-Val-Leu-O-Me 
• 74202-02-1 N-Z-D-valyl-leucine 
• 1685-33-2 N-[(benzyloxy)carbonyl]-D-valine 
• 640-68-6 D-Val-OH 
• 294172-99-9 Boc-D-Val-Leu-Lys(Boc)-OBu 
• 142842-94-2 (S)-6-Benzyloxycarbonylamino-2-[(S)-2-((R)-2-benzyloxycarbonylamino-3-methyl-butyrylamino)-4-methyl-pentanoylamino]-hexanoic acid methyl ester 

Downstream Products

• 88246-15-5 N-6-(benzyloxylcarbonyl)lysyl>-1-β-D-arabinofuranosylcytosine 
• 731767-48-9 {(S)-5-[(S)-2-((R)-2-Benzyloxycarbonylamino-3-methyl-butyrylamino)-4-methyl-pentanoylamino]-5-[methyl-(2-methylamino-ethyl)-carbamoyl]-pentyl}-carbamic acid benzyl ester 
• 294173-05-0 Z-D-Val-Leu-Lys(Z)-N(Me)-(CH₂)2-N(Me)-Boc 

Relevant academic research and scientific papers

Synthesis and biological evaluation of 2'-carbamate-linked and 2'-carbonate-linked prodrugs of paclitaxel selective activation by the tumor-associated protease plasmin

The nontoxic paclitaxel-2'-carbamate prodrugs 2-5 and paclitaxel-2'-carbonate prodrug 6 were synthesized and tested for activation by the tumor-associated enzyme plasmin. A generally applicable method for the synthesis of paclitaxel-2'-carbamates was deve

Synthesis and functional evaluation of a peptide derivative of 1-β-D- arabinofuranosylcytosine

We have synthesized a peptidyl prodrug derivative of 1-β-D- arabinofuranosylcytosine (1) designed to be a selective substrate of plasmin. D-Val-Leu-Lys-ara-C (2) was obtained by coupling the protected peptide Cbz-D- Val-Leu-(N6-Cbz)Lys-OH and a