294176-79-7 Usage
Structure
A five-membered aromatic ring containing one nitrogen atom, with an acetonitrile group and two methyl groups in the 2 and 5 positions.
Type
A derivative of pyrrole
Usage
Organic synthesis, building block for pharmaceuticals and agrochemicals, potential applications in material science and as a precursor for the synthesis of various organic compounds.
Safety
Handle with care, as it may have certain hazards associated with its handling and use.
Check Digit Verification of cas no
The CAS Registry Mumber 294176-79-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,9,4,1,7 and 6 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 294176-79:
(8*2)+(7*9)+(6*4)+(5*1)+(4*7)+(3*6)+(2*7)+(1*9)=177
177 % 10 = 7
So 294176-79-7 is a valid CAS Registry Number.
294176-79-7Relevant articles and documents
Diastereoselective aldolization of α-aminonitriles. Diastereoselective synthesis of β-amino alcohols and β,γ-diamino alcohols
Leclerc, Eric,Vrancken, Emmanuel,Mangeney, Pierre
, p. 8928 - 8937 (2007/10/03)
Aldolization performed by addition of lithiated N-benzyl-N-tert-butylaminoacetonitrile to aldehydes provides diastereomerically pure anti-β-hydroxy-α-aminonitriles. They are transformed into syn,anti-protected β,γ-diamino alcohols by a two-step procedure, involving addition of a Grignard reagent and reduction. The cleavage of the N-tert-butyl group is achieved by a simple acidic treatment. The application of this methodology to chiral, nonracemic aldehydes is studied. Starting from D-isopropylideneglyceraldehyde, an anti, anti, syn, anti-(2R,3S,4S,5R,6R)-diaminotriol is prepared in acceptable yield and with a good level of diastereoselectivity.
