294176-79-7

Basic information

• Product Name: 1H-Pyrrole-1-acetonitrile,2,5-dimethyl-(9CI)
• Synonyms: 1H-Pyrrole-1-acetonitrile,2,5-dimethyl-(9CI)
• CAS NO: 294176-79-7
• Molecular Formula: C₈H₁₀N₂
• Molecular Weight: 134.181
• Product Categories: AMINETERTIARY
• Mol File: 294176-79-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1H-Pyrrole-1-acetonitrile,2,5-dimethyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrole-1-acetonitrile,2,5-dimethyl-(9CI)(294176-79-7)
• EPA Substance Registry System: 1H-Pyrrole-1-acetonitrile,2,5-dimethyl-(9CI)(294176-79-7)

Safety Data

• Hazardous Substances Data: 294176-79-7(Hazardous Substances Data)

Usage

Structure

A five-membered aromatic ring containing one nitrogen atom, with an acetonitrile group and two methyl groups in the 2 and 5 positions.

Type

A derivative of pyrrole

Usage

Organic synthesis, building block for pharmaceuticals and agrochemicals, potential applications in material science and as a precursor for the synthesis of various organic compounds.

Safety

Handle with care, as it may have certain hazards associated with its handling and use.

Upstream product

• 151-63-3 cyanomethylamine sulfate 
• 110-13-4 2,5-hexanedione 
• 1703-51-1 heptane-2,5-dione 

Relevant articles and documents

Diastereoselective aldolization of α-aminonitriles. Diastereoselective synthesis of β-amino alcohols and β,γ-diamino alcohols

Aldolization performed by addition of lithiated N-benzyl-N-tert-butylaminoacetonitrile to aldehydes provides diastereomerically pure anti-β-hydroxy-α-aminonitriles. They are transformed into syn,anti-protected β,γ-diamino alcohols by a two-step procedure, involving addition of a Grignard reagent and reduction. The cleavage of the N-tert-butyl group is achieved by a simple acidic treatment. The application of this methodology to chiral, nonracemic aldehydes is studied. Starting from D-isopropylideneglyceraldehyde, an anti, anti, syn, anti-(2R,3S,4S,5R,6R)-diaminotriol is prepared in acceptable yield and with a good level of diastereoselectivity.

Syntheses of optically active trifluoronorcoronamic acids.

Syntheses of optically active trifluoronorcoronamic acid 6 and its diastereomer 9 are described. Highly stereospecific and diastereoselective S(N)2 cyclization of gamma-cyanohydrins 3a and 3b gave cyclopropyl nitriles 4a and 4b. Hydrolysis of the cyano gr