294199-92-1

Upstream product

• 459-57-4 4-fluorobenzaldehyde 
• 504-02-9 1,3-cylohexanedione 
• 17356-08-0 thiourea 

Downstream Products

• 296761-08-5 3-Amino-5-(4-fluorophenyl)-6-oxo-6,7,8,9-tetrahydro-5H-[1,3]thiazolo[2,3-b]quinazolin-2-carboxamide 
• 296760-93-5 4-(4-fluoro-phenyl)-2-(2-oxo-2-phenyl-ethylsulfanyl)-4,6,7,8-tetrahydro-3H-quinazolin-5-one 
• 294199-83-0 5-(4-Fluorophenyl)-2,3,6,7,8,9-hexahydro-5H-thiazolo[2,3-b]quinazoline-3,6-dione 

Relevant academic research and scientific papers

Multicomponent synthesis of 2,5-dioxo- and 4-aryl-5-oxo-2-thioxo-1,2,3,4,5, 6,7,8-octahydroquinazolines

Ten 2,5-dioxo- and 4-aryl-5-oxo-2-thioxo-1,2,3,4,5,6,7,8- octahydroquinazolines have been synthesized in three-component interactions of 1,3-cyclohexanedione or dimedone, urea or thiourea, and substituted benzaldehydes (3-bromo-, 4-bromo-, 4-fluoro-, 4-methoxy-, 3,4-methylenedioxy-, and 3-nitro-). 9-Aryl-4,5-dioxo-1,2,3,4,5,6,7,8-octahydro-9H-xanthenes were also formed in these reactions.

Chemoselective multicomponent condensation of 1,3-cyclohexanedione, urea or thiourea with aldehydes: One-pot synthesis of two families of fused heterobicyclic and spiro-fused heterobicyclic aliphatic rings

One-pot chemoselective condensation of 1,3-cyclohexanedione, urea or thiourea with aldehydes has been performed by using TMSCI as a Lewis acid in DMF/MeCN. This extended Biginelli-type reaction afforded two families of fused heterobicyclic and spiro-fused

A practical approach towards synthesis of octahydroquinazolinone derivatives in water

A simple, efficient and green procedure has been developed for the synthesis of octahydroquinazolinone derivatives by Biginelli-type three-component cyclocondensation reactions of cyclic β-diketones, aldehydes and (thio)urea with p-TsOH catalysis in water

Synthesis and antifungal activity of novel pyrano[2',3':4,5]thiazolo[2,3-b]quinazolines, pyrido[2',3':4,5]thiazolo[2,3- b]quinazolines and pyrazolo[2',3':4,5]thiazolo[2,3-b]quinazolines

The starting materials thiazolo[2,3-b]quinazolines (5a,b) were obtained in one pot synthesis by treating octahydroquinazoline (2) with chloroacetic acid and aromatic aldehydes. Thiazoloquinazoline (5) was reacted with CH2(CN)2/piperidine and CH2(CN)2/NaOH (CH3OH), to furnish pyrano[2',3':4,5]thiazolo[2,3-b]quinazolines (6a,b) and pyrido[2',3':4,5]thiazolo[2,3-b]quinazoline (7), respectively. Refluxing of 5a with NH2CSNH2/KOH and hydrazines in ethanol furnished the corresponding, [1,3]thiazino[4'5':4,5]thiazolo[2,3-b]quinazoline (10) and pyrazolo[3',4':4,5]thiazolo[2,3-b]quinazolines (11a,b), respectively. Antifungal activity was shown for some of the synthesized compounds. (C) 2000 Elsevier Science S.A.

Synthesis and evaluation of some new fluorinated hydroquinazoline derivatives as antifungal agents

The key intermediate octahydroquinazoline (1) was obtained in one pot synthesis by a modification of the Biginelli reaction. Compound 1 was allowed to react with phenacyl bromide and bromomalononitrile to furnish thiazolo[2,3-b]quinazoline 3 and 12, respectively. Interaction of compound 12 with formamide, formic acid and phenyl isothiocyanate yielded the corresponding pyrimidino[4',5':4,5]thiazolo[2,3-b] quinazolines 13, 14 and 17, respectively. The structure of the synthesized compounds were elucidated by elemental analyses and spectroscopic analyses. Some of the prepared compounds were tested for their antifungal activity in comparison with tioconazole as a reference fungicide. (C) 2000 Elsevier Sciences S.A.