19672-59-4

Usage

Uses

Used in Pharmaceutical Industry:
4,4'-Dichlorochalcone is used as a potential therapeutic agent for its anti-inflammatory properties, which can help in reducing inflammation and related symptoms in various conditions.
Used in Antifungal Applications:
4,4'-Dichlorochalcone is used as an antifungal agent, effective against various fungal infections, providing a potential treatment option for fungal-related diseases.
Used in Antitumor Applications:
4,4'-Dichlorochalcone is used as an antitumor agent, showing potential in inhibiting the growth and progression of cancer cells, making it a candidate for further research in cancer therapy.
Used in Anti-malarial Applications:
4,4'-Dichlorochalcone is used as an antimalarial agent, demonstrating potential in treating and preventing malaria, a significant global health concern.

Upstream product

• 64-17-5 ethanol 
• 104-88-1 4-chlorobenzaldehyde 
• 99-91-2 para-chloroacetophenone 
• 122-00-9 para-methylacetophenone 
• 87275-63-6 2,3-dibromo-1,3-di(4-chlorophenyl)-1-propanone 
• 57-13-6 urea 
• 7647-01-0 hydrogenchloride 
• 7664-93-9 sulfuric acid 
• 64-19-7 acetic acid 
• 19339-59-4 1-(4-chloro-phenyl)-2-thiocyanato-ethanone 
• 13677-54-8 1,3-bis(4-chlorophenyl)prop-2-en-1-ol 
• 141-97-9 ethyl acetoacetate 
• 123-54-6 acetylacetone 
• 1513-29-7 (p-chlorophenyl)methanesulfonyl fluoride 

Downstream Products

• 87275-63-6 2,3-dibromo-1,3-di(4-chlorophenyl)-1-propanone 
• 57845-06-4 3-(4-chlorophenyl)-5-(4-chlorophenyl)-1-phenyl-2-pyrazoline 
• 55902-31-3 (E)-1,3-Bis-(4-chloro-phenyl)-2-nitro-propenone 
• 108325-93-5 3-(4-chlorobenzoyl)-4-(4-chlorophenyl)-4,5-dihydropyrazole 
• 118757-39-4 5,7-Bis-(4-chloro-phenyl)-4,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidine 
• 111336-89-1 5,7-Bis-(4-chloro-phenyl)-3-methyl-1-phenyl-1,6,7,8-tetrahydro-pyrazolo[3,4-b][1,4]diazepine 
• 128917-87-3 4,6-bis(4-chlorophenyl)-2-thioxo-1,2-dihydropyridine-3-carbonitrile 
• 128883-51-2 4,6-di-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydro-3-pyridinecarboxamide 
• 78572-64-2 1-(4-Chloro-benzoyl)-2-(4-chloro-phenyl)-1,2,3,8a-tetrahydro-indolizine-3-carboxylic acid amide 
• 72673-14-4 2,4-Bis(4-chlorophenyl)-6-phenylpyridine 
• 92634-91-8 [(1R,2R,3S)-2-Benzoyl-3-(4-chloro-phenyl)-cyclopropyl]-(4-chloro-phenyl)-methanone 
• 92634-91-8 [(1R,2S,3S)-2-Benzoyl-3-(4-chloro-phenyl)-cyclopropyl]-(4-chloro-phenyl)-methanone 
• 78743-78-9 (4-Chloro-phenyl)-[(1R,2S,3R)-2-(4-chloro-phenyl)-3-(4-methyl-benzoyl)-cyclopropyl]-methanone 
• 78743-78-9 (4-Chloro-phenyl)-[(1R,2S,3S)-2-(4-chloro-phenyl)-3-(4-methyl-benzoyl)-cyclopropyl]-methanone 

Relevant academic research and scientific papers

Solution phase combinatorial synthesis and screening of mini libraries of arylchalcones for antibacterial activity

The solution-phase combinatorial synthesis of aryl chalcones was studied by synthesizing a 6x4 array mini library. The mini libraries of chalcones were synthesized by condensation of 4-substituted acetophenones and various aryl/heteroaryl carbaldehydes. A

Synthesis of tert -Butyl 1,3-Diaryl-3-oxopropylcarbamates by a regiocontrolled reduction of ketoaziridines

A new, convenient approach for the reductive ring opening of N-H ketoaziridines is described. Treatment of N-H ketoaziridines with di-tert-butyl dicarbonate [(Boc)2O] in the presence of sodium iodide and nickel(II) chloride results in the corresponding tert-butyl 1,3-diaryl-3-oxopropylcarbamates by a regiocontrolled reaction. The structure of the regioisomeric product was confirmed by X-ray crystal structure analysis.

Stereo-controlled deamination of ketoaziridines using Ph3P, I2

Ph3P, I2is an efficient reagent for the stereo-controlled deamination of non-activated aziridines, N-H and N-alkyl aziridines, using. The method works gives the corresponding trans-alkenes from both cis and trans-aziridines. A plausible mechanism is proposed for the ring opening and deamination of keto-aziridines in the presence of Ph3P, I2.

Synthesis of lithium/cesium-Zagronas from zagrosian natural asphalt and study of their activity as novel, green, heterogeneous and homogeneous nanocatalysts in the Claisen–Schmidt and Knoevenagel condensations

A novel, heterogeneous and homogeneous basic nanocatalysts were synthesized by grafting of lithium and cesium on zagrosian natural asphalt sulfonate (Li/Cs-Zagronas). The activity of these catalysts was examined in the Claisen–Schmidt and Knoevenagel condensations under mild reaction conditions. Li/Cs-Zagronas were characterized by FT-IR spectroscopy, scanning electron microscopy, X-ray diffraction, energy-dispersive spectroscopy, inductively coupled plasma and thermogravimetric analysis techniques. These nanocatalysts were removed by simple filtration and reused several times without any deterioration of activity.

Synthesis of chalcone derivatives by phthalhydrazide-functionalized tio2-coated nano-fe3o4 as a new heterogeneous catalyst

Phthalhydrazide immobilized on TiO2-coated nano Fe3O4 (Fe3O4-P) was synthesized and characterized by FT-IR, XRD, SEM, EDS and VSM analysis. The resulting magnetic nanocatalyst was used as a catalyst for the synthesis of chalcone derivatives which affords the desired products in good to excellent yields. This catalyst can be isolated readily after completion of the reaction by an external magnetite field and reused several times without significant loss of activity.

Activated charcoal-mediated synthesis of chalcones catalyzed by NaOH in water

A variety of chalcones were synthesized in good yields by the activated charcoal-mediated aldol reactions between benzaldehydes and acetophenones catalyzed by NaOH in water. 2,6-Bis((E)-benzylidene)cyclohexan-1-ones were prepared by the aldol reactions between benzaldehydes and cyclohexanone. Activated charcoal could be recycled five times without the significant decrease of yields.

New nicotinic acid-based 3,5-diphenylpyrazoles: design, synthesis and antihyperlipidemic activity with potential NPC1L1 inhibitory activity

Nicotinic acid hydrazide was incorporated into new 4,5-dihydro-5-hydroxy-3,5-diphenylpyrazol-1-yl derivatives. Compounds 6a–h were synthesized, and their antihyperlipidemic activity was evaluated in high cholesterol diet-fed rat model. Compounds 6e, 6f were found to decrease the levels of serum total cholesterol by 14–19% compared to control group. Total triglycerides were also reduced by 24–28% and LDL cholesterol by 16%. As expected from parent niacin, compounds 6e and 6f caused an elevation of HDL cholesterol by 33–41%. Docking study supported the ability of designed compounds to block NPC1L1 active site in a manner similar to that observed with ezetimibe.

Palladium-Catalyzed Allyl-Allyl Reductive Coupling of Allylamines or Allylic Alcohols with H2as Sole Reductant

Catalytic carbon-carbon bond formation building on reductive coupling is a powerful method for the preparation of organic compounds. The identification of environmentally benign reductants is key for establishing an efficient reductive coupling reaction. Herein an efficient strategy enabling H2 as the sole reductant for the palladium-catalyzed allyl-allyl reductive coupling reaction is described. A wide range of allylamines and allylic alcohols as well as allylic ethers proceed smoothly to deliver the C-C coupling products under 1 atm of H2. Kinetic studies suggested that the dinuclear palladium species was involved in the catalytic cycle.

Boosting the catalytic performance of zinc linked amino acid complex as an eco-friendly for synthesis of novel pyrimidines in aqueous medium

Zinc linked amino acid complex, Zn(l-proline)2, is considered as a green catalyst for the synthesis of novel series of pyrimidine derivatives 5a–q. The pyrimidines 5a–q were prepared via two pathways: the first is a one-pot reaction of guanidines 3a–c with aromatic aldehyde 1 and acetophenones 2; and the second one is the reaction of guanidines 3a–c with different chalcones 4a–j in aqueous medium. The simplicity of the operation, the short reaction time, and the high efficiency (97%) are the main advantages of this protocol. Furthermore, the green aspects of this synthetic protocol were further investigated by examining the reusability of Zn(l-proline)2 complex throughout five consecutive cycles without a significant loss of catalytic activity. This new procedure has presented remarkable advantages in terms of safety, simplicity, stability, mild conditions, a short reaction time, excellent yields, and high purities without using any organic solvents.

Bu4NHSO4-Catalyzed Direct N-Allylation of Pyrazole and its Derivatives with Allylic Alcohols in Water: A Metal-Free, Recyclable and Sustainable System

Allylic amines are valuable and functional building blocks. Direct N-allylation of pyrazole and its derivatives as an atom economic strategy to provide allylic amines has been achieved only using commercial Bu4NHSO4 as the metal-free catalyst and water as the solvent without any additives. 11–93% isolated yields were obtained for the N-allylation of pyrazole and its derivatives with allylic alcohols. Bu4NHSO4 could be reused for six times by simple extraction nearly without loss of catalytic activity and was also suitable for a gram-scale production. The reaction of allylic ether and pyrazole did not occur to give the desired product indicated that allylic ether was not the active intermediate in the pathway. Density functional theory (DFT) calculations reveal that there are hydrogen bonding effects among substrates, solvent and catalyst, especially the one formed between allylic alcohol and H2O. Control experiments in different protic solvents further demonstrate the intermolecular hydrogen bonding of allylic alcohol and water. (Figure presented.).