19672-59-4

Usage

Uses

Used in Pharmaceutical Industry:
4,4'-Dichlorochalcone is used as a potential therapeutic agent for its anti-inflammatory properties, which can help in reducing inflammation and related symptoms in various conditions.
Used in Antifungal Applications:
4,4'-Dichlorochalcone is used as an antifungal agent, effective against various fungal infections, providing a potential treatment option for fungal-related diseases.
Used in Antitumor Applications:
4,4'-Dichlorochalcone is used as an antitumor agent, showing potential in inhibiting the growth and progression of cancer cells, making it a candidate for further research in cancer therapy.
Used in Anti-malarial Applications:
4,4'-Dichlorochalcone is used as an antimalarial agent, demonstrating potential in treating and preventing malaria, a significant global health concern.

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 122-00-9 para-methylacetophenone 
• 7647-01-0 hydrogenchloride 
• 64-19-7 acetic acid 
• 19339-59-4 1-(4-chloro-phenyl)-2-thiocyanato-ethanone 
• 141-97-9 ethyl acetoacetate 
• 123-54-6 acetylacetone 
• 19672-59-4 (E)-1,3-di(4-chlorophenyl)-2-propen-1-one 
• 99-91-2 para-chloroacetophenone 
• 166823-93-4 (2E)-1,3-bis(4-chlorophenyl)prop-2-en-1-ol 
• 873-76-7 para-Chlorobenzyl alcohol 
• 13677-54-8 1,3-bis(4-chlorophenyl)prop-2-en-1-ol 
• 3282-33-5 1-(4-chlorophenyl)-2-diazoethanone 
• 6655-32-9 N'-(4-chlorobenzylidene)-2-nitrobenzenesulfonohydrazide 

Downstream Products

• 87275-63-6 2,3-dibromo-1,3-di(4-chlorophenyl)-1-propanone 
• 55902-31-3 (E)-1,3-Bis-(4-chloro-phenyl)-2-nitro-propenone 
• 108325-93-5 3-(4-chlorobenzoyl)-4-(4-chlorophenyl)-4,5-dihydropyrazole 
• 111336-89-1 5,7-Bis-(4-chloro-phenyl)-3-methyl-1-phenyl-1,6,7,8-tetrahydro-pyrazolo[3,4-b][1,4]diazepine 
• 128883-51-2 4,6-di-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydro-3-pyridinecarboxamide 
• 78572-64-2 1-(4-Chloro-benzoyl)-2-(4-chloro-phenyl)-1,2,3,8a-tetrahydro-indolizine-3-carboxylic acid amide 
• 72673-14-4 2,4-Bis(4-chlorophenyl)-6-phenylpyridine 
• 92634-91-8 [(1R,2R,3S)-2-Benzoyl-3-(4-chloro-phenyl)-cyclopropyl]-(4-chloro-phenyl)-methanone 
• 92634-91-8 [(1R,2S,3S)-2-Benzoyl-3-(4-chloro-phenyl)-cyclopropyl]-(4-chloro-phenyl)-methanone 
• 78743-78-9 (4-Chloro-phenyl)-[(1R,2S,3R)-2-(4-chloro-phenyl)-3-(4-methyl-benzoyl)-cyclopropyl]-methanone 
• 78743-78-9 (4-Chloro-phenyl)-[(1R,2S,3S)-2-(4-chloro-phenyl)-3-(4-methyl-benzoyl)-cyclopropyl]-methanone 
• 123033-11-4 [(1R,2R)-2-(4-Chloro-benzoyl)-3-(4-chloro-phenyl)-cyclopropyl]-(4-chloro-phenyl)-methanone 
• 123033-11-4 [(1R,2S,3S)-2-(4-Chloro-benzoyl)-3-(4-chloro-phenyl)-cyclopropyl]-(4-chloro-phenyl)-methanone 
• 74918-93-7 2-(4-Bromo-phenyl)-4,6-bis-(4-chloro-phenyl)-pyridine 

Relevant academic research and scientific papers

Solution phase combinatorial synthesis and screening of mini libraries of arylchalcones for antibacterial activity

The solution-phase combinatorial synthesis of aryl chalcones was studied by synthesizing a 6x4 array mini library. The mini libraries of chalcones were synthesized by condensation of 4-substituted acetophenones and various aryl/heteroaryl carbaldehydes. A

Synthesis of tert -Butyl 1,3-Diaryl-3-oxopropylcarbamates by a regiocontrolled reduction of ketoaziridines

A new, convenient approach for the reductive ring opening of N-H ketoaziridines is described. Treatment of N-H ketoaziridines with di-tert-butyl dicarbonate [(Boc)2O] in the presence of sodium iodide and nickel(II) chloride results in the corresponding tert-butyl 1,3-diaryl-3-oxopropylcarbamates by a regiocontrolled reaction. The structure of the regioisomeric product was confirmed by X-ray crystal structure analysis.

Stereo-controlled deamination of ketoaziridines using Ph3P, I2

Ph3P, I2is an efficient reagent for the stereo-controlled deamination of non-activated aziridines, N-H and N-alkyl aziridines, using. The method works gives the corresponding trans-alkenes from both cis and trans-aziridines. A plausible mechanism is proposed for the ring opening and deamination of keto-aziridines in the presence of Ph3P, I2.

Novel potent and selective DPP-4 inhibitors: Design, synthesis and molecular docking study of dihydropyrimidine phthalimide hybrids

Background: Dipeptidyl peptidase-4 (DPP-4) inhibitors have emerged as antihyperglycemic agents that improve glycemic control in type 2 diabetic patients, either as monotherapy or in combination with other antidiabetic drugs. Methods: A novel series of dihydropyrimidine phthalimide hybrids was synthesized and evaluated for their in vitro and in vivo DPP-4 inhibition activity and selectivity using alogliptin as reference. Oral glucose tolerance test was assessed in type 2 diabetic rats after chronic treatment with the synthesized hybrids ± metformin. Cytotoxicity and antioxidant assays were performed. Additionally, molecular docking study with DPP-4 and structure activity relationship of the novel hybrids were also studied. Results: Among the synthesized hybrids, 10g, 10i, 10e, 10d and 10b had stronger in vitro DPP-4 inhibitory activity than alogliptin. Moreover, an in vivo DPP-4 inhibition assay revealed that 10g and 10i have the strongest and the most extended blood DPP-4 inhibitory activity compared to alogliptin. In type 2 diabetic rats, hybrids 10g, 10i and 10e exhibited better glycemic control than alogliptin, an effect that further supported by metformin combination. Finally, 10j, 10e, 10h and 10d had the highest radical scavenging activity in DPPH assay. Conclusions: Hybrids 10g, 10i and 10e are potent DPP-4 inhibitors which may be beneficial for T2DM treatment.

Modular access to 1,2-allenyl ketones based on a photoredox-catalysed radical-polar crossover process

Herein, a new protocol dealing with the preparation of 1,2-allenyl ketones has been successfully developedviathe reactions of enynes with radicals enabled by dual photoredox/copper catalysis. Based on the results of a deuteration experiment and the competition reaction between cyclopropanation and allenation, the mechanism based on a photoredox-neutral-catalysed radical-polar crossover process has been proposed. Synthetic applications of allenes have also been demonstrated.

Synthesis of lithium/cesium-Zagronas from zagrosian natural asphalt and study of their activity as novel, green, heterogeneous and homogeneous nanocatalysts in the Claisen–Schmidt and Knoevenagel condensations

A novel, heterogeneous and homogeneous basic nanocatalysts were synthesized by grafting of lithium and cesium on zagrosian natural asphalt sulfonate (Li/Cs-Zagronas). The activity of these catalysts was examined in the Claisen–Schmidt and Knoevenagel condensations under mild reaction conditions. Li/Cs-Zagronas were characterized by FT-IR spectroscopy, scanning electron microscopy, X-ray diffraction, energy-dispersive spectroscopy, inductively coupled plasma and thermogravimetric analysis techniques. These nanocatalysts were removed by simple filtration and reused several times without any deterioration of activity.

Synthesis of chalcone derivatives by phthalhydrazide-functionalized tio2-coated nano-fe3o4 as a new heterogeneous catalyst

Phthalhydrazide immobilized on TiO2-coated nano Fe3O4 (Fe3O4-P) was synthesized and characterized by FT-IR, XRD, SEM, EDS and VSM analysis. The resulting magnetic nanocatalyst was used as a catalyst for the synthesis of chalcone derivatives which affords the desired products in good to excellent yields. This catalyst can be isolated readily after completion of the reaction by an external magnetite field and reused several times without significant loss of activity.

Activated charcoal-mediated synthesis of chalcones catalyzed by NaOH in water

A variety of chalcones were synthesized in good yields by the activated charcoal-mediated aldol reactions between benzaldehydes and acetophenones catalyzed by NaOH in water. 2,6-Bis((E)-benzylidene)cyclohexan-1-ones were prepared by the aldol reactions between benzaldehydes and cyclohexanone. Activated charcoal could be recycled five times without the significant decrease of yields.

New nicotinic acid-based 3,5-diphenylpyrazoles: design, synthesis and antihyperlipidemic activity with potential NPC1L1 inhibitory activity

Nicotinic acid hydrazide was incorporated into new 4,5-dihydro-5-hydroxy-3,5-diphenylpyrazol-1-yl derivatives. Compounds 6a–h were synthesized, and their antihyperlipidemic activity was evaluated in high cholesterol diet-fed rat model. Compounds 6e, 6f were found to decrease the levels of serum total cholesterol by 14–19% compared to control group. Total triglycerides were also reduced by 24–28% and LDL cholesterol by 16%. As expected from parent niacin, compounds 6e and 6f caused an elevation of HDL cholesterol by 33–41%. Docking study supported the ability of designed compounds to block NPC1L1 active site in a manner similar to that observed with ezetimibe.

Palladium-Catalyzed Allyl-Allyl Reductive Coupling of Allylamines or Allylic Alcohols with H2as Sole Reductant

Catalytic carbon-carbon bond formation building on reductive coupling is a powerful method for the preparation of organic compounds. The identification of environmentally benign reductants is key for establishing an efficient reductive coupling reaction. Herein an efficient strategy enabling H2 as the sole reductant for the palladium-catalyzed allyl-allyl reductive coupling reaction is described. A wide range of allylamines and allylic alcohols as well as allylic ethers proceed smoothly to deliver the C-C coupling products under 1 atm of H2. Kinetic studies suggested that the dinuclear palladium species was involved in the catalytic cycle.