29427-48-3

Usage

Uses

2'-Fluoro-4'-methylacetophenone is used as an intermediate in pharmaceuticals.

Upstream product

• 352-70-5 m-Fluorotoluene 
• 75-36-5 acetyl chloride 
• 122-00-9 para-methylacetophenone 

Downstream Products

• 1232892-63-5 1-(2-Fluoro-4-methyl-5-nitro-phenyl)-ethanone 
• 1184949-31-2 4-benzyloxy-1-[2-(2-fluoro-4-hydroxymethyl-phenyl)-2-oxo-ethyl]-1H-pyridin-2-one 
• 1184949-28-7 acetic acid 4-acetyl-3-fluoro-benzyl ester 
• 1184949-30-1 2-bromo-1-(2-fluoro-4-hydroxymethyl-phenyl)-ethanone 
• 1184949-29-8 1-(2-fluoro-4-hydroxymethyl-phenyl)-ethanone 
• 1431285-41-4 1-(2-fluoro-4-methylphenyl)ethanone 2-(2,4-difluorophenyl)hydrazone 
• 1431277-64-3 methyl 1-[[1-(2,4-difluorophenyl)-3-(2-fluoro-4-methylphenyl)-1H-pyrazol-4-yl]methyl]-4-piperidinecarboxylate 
• 1431285-42-5 1-(2,4-difluorophenyl)-3-(2-fluoro-4-methylphenyl)-1H-pyrazole-4-carboxaldehyde 

Relevant academic research and scientific papers

Pd-Catalysed direct C(sp2)-H fluorination of aromatic ketones: Concise access to anacetrapib

The Pd-cataylsed direct ortho-C(sp2)-H fluorination of aromatic ketones has been developed for the first time. The reaction features good regioselectivity and simple operations, constituting an alternative shortcut to access fluorinated ketones. A concise synthesis of anacetrapib has also been achieved by using late-stage C-H fluorination as a key step.

Simple and environment-friendly chemical synthesis method of 4-fluoro-2-methyl benzoic acid

The invention relates to a simple and environment-friendly chemical synthesis method of 4-fluoro-2-methyl benzoic acid. According to the synthesis method, m-fluorotoluene and acetyl chloride are takenas starting raw materials, and are subjected to a Friedel-Crafts acylation reaction under the catalytic action of anhydrous aluminum trichloride, a haloform reaction is carried out with sodium hypochlorite, two isomers of 4-fluoro-2-methyl benzoic acid and 2-fluoro-4-methyl benzoic acid are simultaneously obtained after hydrolysis, and the isomers are separated through re-crystallizing so as to obtain the target product 4-fluoro-2-methylbenzoic acid. The route is mild in reaction condition, low in cost, environment-friendly and suitable for industrial production.