29427-48-3

Basic information

• Product Name: 2'-FLUORO-4'-METHYLACETOPHENONE
• Synonyms: 2'-FLUORO-4'-METHYLACETOPHENONE;1-(2-Fluoro-4-methylphenyl)ethan-1-one, 4-Acetyl-3-fluorotoluene;1-(2-fluoro-4-Methylphenyl)ethanone
• CAS NO: 29427-48-3
• Molecular Formula: C₉H₉FO
• Molecular Weight: 152.17
• Mol File: 29427-48-3.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 213.5°Cat760mmHg
• Flash Point: 81.5°C
• Appearance: /
• Density: 1.075g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2'-FLUORO-4'-METHYLACETOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2'-FLUORO-4'-METHYLACETOPHENONE(29427-48-3)
• EPA Substance Registry System: 2'-FLUORO-4'-METHYLACETOPHENONE(29427-48-3)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 29427-48-3(Hazardous Substances Data)

Usage

Uses

2'-Fluoro-4'-methylacetophenone is used as an intermediate in pharmaceuticals.

Upstream product

• 122-00-9 para-methylacetophenone 
• 352-70-5 m-Fluorotoluene 
• 75-36-5 acetyl chloride 

Downstream Products

• 1184949-31-2 4-benzyloxy-1-[2-(2-fluoro-4-hydroxymethyl-phenyl)-2-oxo-ethyl]-1H-pyridin-2-one 
• 1184949-28-7 acetic acid 4-acetyl-3-fluoro-benzyl ester 
• 1184949-30-1 2-bromo-1-(2-fluoro-4-hydroxymethyl-phenyl)-ethanone 
• 1184949-29-8 1-(2-fluoro-4-hydroxymethyl-phenyl)-ethanone 
• 1431285-41-4 1-(2-fluoro-4-methylphenyl)ethanone 2-(2,4-difluorophenyl)hydrazone 
• 1431277-64-3 methyl 1-[[1-(2,4-difluorophenyl)-3-(2-fluoro-4-methylphenyl)-1H-pyrazol-4-yl]methyl]-4-piperidinecarboxylate 
• 1431285-42-5 1-(2,4-difluorophenyl)-3-(2-fluoro-4-methylphenyl)-1H-pyrazole-4-carboxaldehyde 
• 1431705-43-9 1-(2-(3,4-dihydroisoquinolin-2(1H)-yl)-4-methylphenyl)ethanone 

Relevant articles and documents

Pd-Catalysed direct C(sp2)-H fluorination of aromatic ketones: Concise access to anacetrapib

The Pd-cataylsed direct ortho-C(sp2)-H fluorination of aromatic ketones has been developed for the first time. The reaction features good regioselectivity and simple operations, constituting an alternative shortcut to access fluorinated ketones. A concise synthesis of anacetrapib has also been achieved by using late-stage C-H fluorination as a key step.