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3'-Hydroxyphenyl salicylate, also known as 2-hydroxy-3-(2-hydroxyphenyl)benzoic acid, is an organic compound with the molecular formula C13H10O4. It is a white crystalline solid that is soluble in organic solvents and has a melting point of 185-187°C. 3'-hydroxyphenyl salicylate is derived from the combination of salicylic acid and 3-hydroxyphenol, and it exhibits various biological activities, such as antioxidant, anti-inflammatory, and antipyretic properties. It is used in the synthesis of pharmaceuticals, particularly in the preparation of nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin, which is a widely used medication for pain relief, fever reduction, and inflammation. The compound's structure and properties make it a valuable intermediate in the chemical industry, contributing to the development of various therapeutic agents.

2944-56-1

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2944-56-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 2944-56-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,9,4 and 4 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 2944-56:
(6*2)+(5*9)+(4*4)+(3*4)+(2*5)+(1*6)=101
101 % 10 = 1
So 2944-56-1 is a valid CAS Registry Number.

2944-56-1Downstream Products

2944-56-1Relevant academic research and scientific papers

Acylation of Phenols with Salicylic Acid Using Polyphosphoric Acid

Kamat, S. P.,Paknikar, S. K.

, p. 773 - 774 (2007/10/02)

Acylation of 2-naphthol (2), 1-naphthol (6) and resorcinol (11) with salicylic acid (1) in the presence of PPA affords salicylate esters (4, 7, 13 and 14), 1,2-benzoxanthone (5), 3,4-benzoxanthone (8), 3-hydroxyxanthone (12), 2-salicoyl-1-naphthol (9) and 11-hydroxy-12H-benzoxanthen-12-one (10).Compounds (4, 5, 7, 8, 12, 13 and 14) are identical with those obtained by heating a mixture of phenyl salicylate (3) and phenols (2, 6 and 11).

Thermal Conversion of Salol into Xanthone: A Mechanistic Study

Kamat, S. P.,Paknikar, S. K.

, p. 38 - 41 (2007/10/02)

The thermal conversion of salol (1) into xanthone has been rationalized as proceeding via the keto-ketene intermediate (7) which is trapped by phenols (9, 12 and 15).

Studies in Synthesis of Xanthone Derivatives: Part III+ - A New One-step Synthesis of Xanthones

Patolia, Ravji J.,Trivedi, K. N.

, p. 444 - 447 (2007/10/02)

Ethyl salicylate condenses with different phenols in refluxing diphenyl ether to give various xanthones in good yields.In the case of resorcinol, hydroquinone, catechol and 3,4-xylenol corresponding phenyl salicylate derivatives are also obtained.Condensation with hydroxycoumarins affords pyranoxanthones, which can not be prepared by the Pechmann condensation of hydroxyxanthones.The structures of the intermediates and final products are established by spectral data (IR, PMR and 13C NMR).

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