29445-16-7

Upstream product

• 40358-30-3 2,3-dihydro-2,4-diphenyl-1H-benzo[b][1,5]diazepine 
• 1625-85-0 2,4-diphenyl-3H-1,5-benzodiazepine 
• 95-54-5 1,2-diamino-benzene 
• 120-46-7 1,3-diphenylpropanedione 

Downstream Products

• 83352-97-0 1-((2R,4R)-2,4-Diphenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl)-ethanone 
• 83352-97-0 1-((2R,4S)-2,4-Diphenyl-2,3,4,5-tetrahydro-benzo[b][1,4]diazepin-1-yl)-ethanone 
• 1393093-17-8 (S,S)-5-N-(p-Br-benzoyl)-2,4-diphenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine 

Relevant academic research and scientific papers

Tetrahydroquinoline skeleton chiral phosphine-nitrogen ligand and preparation method and application thereof

The invention relates to the field of asymmetric catalytic hydrogenation, in particular to a tetrahydroquinoline skeleton chiral phosphine-nitrogen ligand and a preparation method and application thereof. The tetrahydroquinoline skeleton chiral phosphine-

Dynamic Kinetic Resolution Approach for the Asymmetric Synthesis of Tetrahydrobenzodiazepines Using Transfer Hydrogenation by Chiral Phosphoric Acid

Asymmetric synthesis of tetrahydrobenzodiazepines was achieved by transfer hydrogenation of dihydrobenzodiazepines with benzothiazoline having a hydrogen-bonding donor substituent by means of a newly synthesized chiral phosphoric acid. This method was applicable to various racemic dihydrobenzodiazepines to give the corresponding products in good yields with excellent diastereoselectivities and enantioselectivities taking advantage of the dynamic kinetic resolution. Furthermore, the effect of bulky substituent at 3,3′-position on the catalyst and hydrogen-bonding donor substituent on benzothiazoline was fully elucidated by the theoretical study.

Asymmetric hydrogenation of 2,4-disubstituted 1,5-benzodiazepines using cationic ruthenium diamine catalysts: An unusual achiral counteranion induced reversal of enantioselectivity

BArFing it out the other way: A highly enantioselective hydrogenation of 2,4-disubstituted 1,5-benzodiazepines using chiral cationic ruthenium diamine catalysts (R,R)-1 has been developed (see scheme; BArF=tetrakis(3,5- bistrifluoromethylphenyl)borate). E

Chemical transformations of 2,4-diaryl-2,3-dihydro-1H,1,5-benzodiazepines

The behavior of 2,4-diphenyl-2,3-dihydro-1H-1,5-benzodiazepine in acylation, alkylation, nitrosation, oxidation, reduction, salt formation, and opening of the diazepine ring under the influence of various dinucleophiles and acids was studied. It is shown that the dihydrodiazepine ring is extremely sensitive to acidic reagents and undergoes rearrangement to an imidazole ring under their influence. The structure of the cis- and trans-tetrahydroazepines were analyzed thoroughly.