1625-85-0

Upstream product

• 40358-30-3 2,3-dihydro-2,4-diphenyl-1H-benzo[b][1,5]diazepine 
• 591-50-4 iodobenzene 
• 536-74-3 phenylacetylene 
• 95-54-5 1,2-diamino-benzene 
• 7338-94-5 1,3-diphenyl-2-propynone 
• 21772-11-2 1,4-diphenylbutan-3-yn-2-one 

Downstream Products

• 1393092-52-8 (2S,4S)-2,4-diphenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine 
• 29445-16-7 2,4-Diphenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine 
• 2183-27-9 1,3,5-triphenyl-1H-pyrazole 
• 10173-29-2 2-benzyl-3-phenylquinoxaline 
• 112055-30-8 1,3-dichloro-1a,2a-diphenyl-1,1a,2a,3-tetrahydro-2H-bisazirino<1,2-a:2',1'-d><1,5>benzodiazepine 
• 80948-04-5 2,3,4a,6-tetraphenyl-4a,11b-dihydro-1H,5H-1,3-oxazino<3,2-a>-1,5-benzodiazepin-1-on 
• 112055-27-3 C₂₃H₁₆Br₄N₂ 
• 112055-26-2 C₂₃H₁₆Cl₄N₂ 
• 29445-16-7 2,4-diphenyl-2,3,4,5-tetrahydro-1H-1,5-benzodiazepine 
• 358333-16-1 diethyl (2,4-diphenyl-3H-1,5-benzodiazepin-3-yl)malonate 
• 358333-14-9 3-bromo-2,4-diphenyl-3H-1,5-benzodiazepine 

Relevant academic research and scientific papers

Method for preparing benzodiazepine compound through efficient catalysis of pyridine palladium

The invention discloses a method for preparing a benzodiazepine compound through efficient catalysis of pyridine palladium. According to the method, an iodobenzene compound, an aryl alkyne compound, an o-phenylene diamine compound and carbon monoxide are

A sustainable water-tolerant catalyst with enhanced Lewis acidity: Dual activation of Cp2TiCl2 via ligand and solvent

A new strategy was developed to enhance the activity of titanocene dichloride for the synthesis of 2,4-disubstituted-3H-benzo[b]-[1,4]diazepine derivatives by using Cp2TiCl2 as a pre-catalyst. The titanocene was activated in situ in the catalytic system via the coordination with m-phthalic acid and alcohol solvent accompanied with the secession of a cyclopentadienyl ring, leading to the formation of an activated species, [CpTi(OEt)2(η1-C8H5O4)]. In particular, the novel developed half-titanocene catalyst exhibited more superior stability than representative half-titanocene complex, indicated by not only water compatibility for the employment of 30 % aqueous ethanol solution but also the recyclability that the products could be generated without apparent yield decrease after 5 runs. In general, we present a paradigm for sustainable molecular catalysis of titanocene.

Method for catalytically preparing benzodiazepine compound by using titanocene dichloride

The invention discloses a method for catalytically preparing a benzodiazepine compound by using titanocene dichloride. According to the method, a 3-butyne-2-ketone compound and an o-phenylenediamine compound are taken as raw materials, ethanol or methanol

Recyclable gallium(III) triflate-catalyzed [4+3] cycloaddition for synthesis of 2,4-disubstituted-3H-benzo[b][1,4]diazepines

Simple and efficient Ga(OTf)3-catalyzed [4+3] cycloaddition of 1,3-diarylpropynones and o-phenylenediamines is developed for the preparation of 2,4-disubstituted-3H-benzo[b][1,4]diazepines. The reaction has advantages of using a green solvent, generating a minimal amount of waste, and easy catalyst recycle.

Chemical transformations of 2,4-diaryl-2,3-dihydro-1H,1,5-benzodiazepines

The behavior of 2,4-diphenyl-2,3-dihydro-1H-1,5-benzodiazepine in acylation, alkylation, nitrosation, oxidation, reduction, salt formation, and opening of the diazepine ring under the influence of various dinucleophiles and acids was studied. It is shown that the dihydrodiazepine ring is extremely sensitive to acidic reagents and undergoes rearrangement to an imidazole ring under their influence. The structure of the cis- and trans-tetrahydroazepines were analyzed thoroughly.

The Reaction of 2,4,6-Triphenyl-1,3-oxazinylium Perchlorate with Amino Compounds

The reaction of 2,4,6-triphenyl-1,3-oxazinylium perchlorate with various kinds of amino compounds was studied.Primary amines and semicarbazides gave pyrimidinium perchlorates. o-Phenylenediamine, 0-aminobenzamide, and o-aminothiophenol afforded 2,4-diphenyl-1,5-benzodiazepine, 2-phenyl-4-hydroxyquinazoline, and 2-phenyl-1,3-benzothiazole respectively.Benzoylhydrazine, 4-pyridinecarbohydrazine, and 4-phenylthiosemicarbazide all led to pyrazoline derivatives.N,N-Dimethylhydrazine yielded two chain products competitively, while N,N'-dimethylhydrazine gave 1,2-dimethyl-3,5-diphenyl-1,2,4-triazolylium and 1,2-dimethyl-3,5-diphenyl-pyrazoly lium perchlorate competitively.It was thus shown that 2,4,6-triphenyl-1,3-oxazinylium perchlorate reacts with amino compounds in a complicated fashion to afford various heterocyclic compounds and other derivatives.