294619-46-8Relevant academic research and scientific papers
Anti-tumor promoting effects of sesquiterpenes from Maytenus cuzcoina (celastraceae)
Gonzalez, Antonio G.,Tincusi, Benigna M.,Bazzocchi, Isabel L.,Tokuda, Harukuni,Nishino, Hoyoku,Konoshima, Takao,Jimenez, Ignacio A.,Ravelo, Angel G.
, p. 1773 - 1778 (2000)
Ten sesquiterpenoids (1-10), with a dihydro-β-agarofuran skeleton, were isolated from Maytenus cuzcoina (Celastraceae). Their structures were elucidated on the basis of spectral analysis, including homo- and heteronuclear correlations NMR experiments (COSY, ROESY, HMQC and HMBC), and chemical correlations. The compounds have been tested for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), as a test for potential cancer chemopreventive agents. Compounds 1-3, 6 and 7 showed strong inhibitory effects on EBV-EA induction (100% inhibition at 1000 mol ratio/TPA). Their structure-activity relationship is discussed. Copyright (C) 2000 Elsevier Science Ltd.
