294653-58-0

Basic information

• Product Name: Ethyl 4-(3-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
• Synonyms: Ethyl 4-(3-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
• CAS NO: 294653-58-0
• Molecular Formula: C₁₄H₁₆N₂O₄
• Molecular Weight: 276.28784
• Mol File: 294653-58-0.mol
• Article Data: 82

Chemical Properties

• Melting Point: 187-188 °C(Solv: ethyl acetate (141-78-6); ligroine (8032-32-4))
• Boiling Point: 439.3±45.0 °C(Predicted)
• Appearance: /
• Density: 1.250±0.06 g/cm3(Predicted)
• PKA: 9.74±0.10(Predicted)
• CAS DataBase Reference: Ethyl 4-(3-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 4-(3-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate(294653-58-0)
• EPA Substance Registry System: Ethyl 4-(3-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate(294653-58-0)

Safety Data

• Hazardous Substances Data: 294653-58-0(Hazardous Substances Data)

Upstream product

• 620-24-6 3-Hydroxybenzyl alcohol 
• 851778-73-9 C₁₆H₁₈N₂O₅ 
• 141-97-9 ethyl acetoacetate 
• 57-13-6 urea 
• 100-83-4 meta-hydroxybenzaldehyde 

Downstream Products

• 1386328-60-4 ethyl 4-(3-(2-chloro-7-methylquinolin-4-yloxy)phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1386328-73-9 ethyl 4-(3-(2-chlorobenzo[h]quinolin-4-yloxy)phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1386328-71-7 ethyl 4-(3-(2-chloro-6,8-dimethylquinolin-4-yloxy) phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1386328-69-3 ethyl 4-(3-(6-bromo-2-chloroquinolin-4-yloxy) phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1386328-66-0 ethyl 4-(3-(2,7-dichloroquinolin-4-yloxy)phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1386328-65-9 ethyl 4-(3-(2-chloro-8-methoxyquinolin-4-yloxy) phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1386328-64-8 ethyl 4-(3-(2-chloro-6-methoxyquinolin-4-yloxy) phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1386328-62-6 ethyl 4-(3-(2-chloro-8-methylquinolin-4-yloxy)phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1386328-59-1 ethyl 4-(3-(2-chloro-6-methylquinolin-4-yloxy)phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1224681-21-3 4-(3-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid 

Relevant articles and documents

Shape-controlled synthesis of sodium zincate mesoporous structures based on sulfonated melamine formaldehyde and their application as catalysts for Biginelli reaction

In the current research, two mesoporous structures of sodium zincate [Na2Zn(OH)4], spheres and aggregated particles, has been synthesized from sulfonation of melamine-formaldehyde (MF) and then bounding [Na2Zn(OH)4] particles onto the surface of sulfonated melamine–formaldehyde (SMF). Furthermore, in the present synthetic methodology the zinc oxide (ZnO) thin films on sulfonated melamine–formaldehyde was formed via the chemical deposition, and thermal treatment techniques of the sodium zincate. Several spectroscopic and analytical methods proved the structural and morphological properties of sodium zincate mesoporous structures based on sulfonated melamine formaldehyde [SMF/Na2Zn(OH)4]. The experimental studies showed that these catalytic systems showed high activity in the Biginelli reaction for the synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives and will find recoverable potential application. The obtained results indicated that the synthesized mesoporous structures had a thermal stability near 300 °C, particle-size distribution around of 10–120 nm for spheres and the surface area of 6 and 2 m2/g for spheres and aggregated particles, respectively.

Amine-functionalized nano-NaY zeolite for the synthesis of N-acetyl pyrazoles and dihydropyrimidines

An efficient base-catalyzed synthesis of dihydropyrimidines and N-acetyl pyrazoles is reported using 1-(2-aminoethyl)piperazine-modified nano-NaY zeolite (ZeSi–AP) under mild and green conditions. The structure of the catalyst was identified by using FT-IR, XRD, TGA, DTA, DLS, SEM, TEM, and elemental analyses. This heterogeneous catalyst has many benefits, such as a simple work-up procedure, high product yield, and it is easily regenerated and reused at least for four cycles without losing its activity.

Synthesis and Evaluation of Dihydropyrimidinones and Their Derivatives against Meloidogyne incognita

3,4-Dihydropyrimidin-2-ones (DHPMs) were synthesized in good yield using ammonium molybdate as a catalyst under different reaction conditions through ultrasonication technique. Dehydrogenated derivatives of DHPMs, that is, pyrimidin-2-ones were synthesize