294653-58-0

Upstream product

• 141-97-9 ethyl acetoacetate 
• 100-83-4 meta-hydroxybenzaldehyde 
• 57-13-6 urea 
• 620-24-6 3-Hydroxybenzyl alcohol 
• 851778-73-9 C₁₆H₁₈N₂O₅ 

Downstream Products

• 1386328-60-4 ethyl 4-(3-(2-chloro-7-methylquinolin-4-yloxy)phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1386328-73-9 ethyl 4-(3-(2-chlorobenzo[h]quinolin-4-yloxy)phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1386328-71-7 ethyl 4-(3-(2-chloro-6,8-dimethylquinolin-4-yloxy) phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1386328-69-3 ethyl 4-(3-(6-bromo-2-chloroquinolin-4-yloxy) phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1386328-66-0 ethyl 4-(3-(2,7-dichloroquinolin-4-yloxy)phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1386328-65-9 ethyl 4-(3-(2-chloro-8-methoxyquinolin-4-yloxy) phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1386328-64-8 ethyl 4-(3-(2-chloro-6-methoxyquinolin-4-yloxy) phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1386328-62-6 ethyl 4-(3-(2-chloro-8-methylquinolin-4-yloxy)phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1386328-59-1 ethyl 4-(3-(2-chloro-6-methylquinolin-4-yloxy)phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate 
• 1224681-21-3 4-(3-hydroxyphenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid 

Relevant academic research and scientific papers

Shape-controlled synthesis of sodium zincate mesoporous structures based on sulfonated melamine formaldehyde and their application as catalysts for Biginelli reaction

In the current research, two mesoporous structures of sodium zincate [Na2Zn(OH)4], spheres and aggregated particles, has been synthesized from sulfonation of melamine-formaldehyde (MF) and then bounding [Na2Zn(OH)4] particles onto the surface of sulfonated melamine–formaldehyde (SMF). Furthermore, in the present synthetic methodology the zinc oxide (ZnO) thin films on sulfonated melamine–formaldehyde was formed via the chemical deposition, and thermal treatment techniques of the sodium zincate. Several spectroscopic and analytical methods proved the structural and morphological properties of sodium zincate mesoporous structures based on sulfonated melamine formaldehyde [SMF/Na2Zn(OH)4]. The experimental studies showed that these catalytic systems showed high activity in the Biginelli reaction for the synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives and will find recoverable potential application. The obtained results indicated that the synthesized mesoporous structures had a thermal stability near 300 °C, particle-size distribution around of 10–120 nm for spheres and the surface area of 6 and 2 m2/g for spheres and aggregated particles, respectively.

Chemistry, anti-diabetic activity and structural analysis of substituted dihydropyrimidine analogues

In an effort to identify an anti-diabetic agent, a series of methyl/ethyl 4-(hydroxyphenyl)-6-methyl-2-oxo/thioxo-1,2,3,4 tetrahydropyrimidine-5-carboxylate analogues (4a-h) have been synthesized, purified, and characterized by using Fourier-Transform Inf

Amine-functionalized nano-NaY zeolite for the synthesis of N-acetyl pyrazoles and dihydropyrimidines

An efficient base-catalyzed synthesis of dihydropyrimidines and N-acetyl pyrazoles is reported using 1-(2-aminoethyl)piperazine-modified nano-NaY zeolite (ZeSi–AP) under mild and green conditions. The structure of the catalyst was identified by using FT-IR, XRD, TGA, DTA, DLS, SEM, TEM, and elemental analyses. This heterogeneous catalyst has many benefits, such as a simple work-up procedure, high product yield, and it is easily regenerated and reused at least for four cycles without losing its activity.

A Br?nsted acidic ionic liquid anchored to magnetite nanoparticles as a novel recoverable heterogeneous catalyst for the Biginelli reaction

In this study, simple and effective methods were used for the preparation of an ionic liquid that immobilized magnetite nanoparticles. Fe3O4nanoparticles were preparedviaa chemical co-precipitation method. Then, a SiO2shel

Synthesis and Evaluation of Dihydropyrimidinones and Their Derivatives against Meloidogyne incognita

3,4-Dihydropyrimidin-2-ones (DHPMs) were synthesized in good yield using ammonium molybdate as a catalyst under different reaction conditions through ultrasonication technique. Dehydrogenated derivatives of DHPMs, that is, pyrimidin-2-ones were synthesize

Natural dolomitic limestone-catalyzed synthesis of benzimidazoles, dihydropyrimidinones, and highly substituted pyridines under ultrasound irradiation

Natural dolomitic limestone (NDL) is employed as a heterogeneous green catalyst for the synthesis of medicinally valuable benzimidazoles, dihydropyrimidinones, and highly functionalized pyridines via C–N, C–C, and C–S bond formations in a mixture of ethan

Efficient biocatalytic strategy for one-pot Biginelli reaction via enhanced specific effects of microwave in a circulating reactor

A one-pot efficient biocatalytic strategy for the synthesis of 3,4-dihydropyrimidin-2-(1H)-ones was developed in a circulating microwave reactor selecting α-chymotrypsin as the promiscuous biocatalyst. In the circulating reaction system, the combination o

An efficient and recyclable L-proline triflate ionic liquid catalyst for one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones via the multi-component Biginelli reaction

A simple, efficient, and environmentally-friendly process has been developed for the synthesis of L-proline triflate ionic liquid (L-ProTfO) from L-proline and triflic acid using ultrasound irradiation. The combination of L-proline triflate ionic liquid t

Photo-oxidation coupled Kabachnik-Fields and Bigenelli reactions for direct conversion of benzyl alcohols to α-aminophosphonates and dihydropyrimidones

A tandem one-pot solvent free approach for the direct conversion of benzyl alcohols to α-amino phosphonates and dihydropyrimidones is reported. The method relies on a metal free photo-oxidation of benzyl alcohols to benzaldehydes under UV irradiation using ammonium perchlorate followed by Kabachnik-Fields and Biginelli reactions. The reaction conditions are moderate and metal free with good substrate scope. The control experiments were performed to investigate the role of the ammonium perchlorate and molecular oxygen as oxidants. The quenching experiments in the presence of TEMPO and other radical quenchers suggest radical based mechanism.

A highly efficient one-pot multicomponent synthesis of 3,4-dihydropyrimidin-2-(1H)-ones/thiones catalyzed by strontium pyroarsenate nano-plates

The present work describes the one-pot multicomponent synthesis of heterocyclic 3,4-dihydropyrimidin-2-(1H)-ones and thiones (DHPMs) under solvent-free conditions by Sr2As2O7 nanocatalyst. Sr2As2Osub