29475-60-3Relevant academic research and scientific papers
Synthesis of non-natural cofactor analogs of S-adenosyl-L-methionine using methionine adenosyltransferase
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Page/Page column 30; 33; 38, (2018/02/28)
The present disclosure relates to the synthesis of non-natural analogs of S-adenosyl-L-methionine (SAM) and/or of Se-adenosyl-L-methionine (SeAM) by reacting a methionine analog and adenosine triphosphate (ATP) in the presence of at least one methionine adenosyltransferase (MAT), and to use thereof with downstream SAM and/or SeAM utilizing enzymes. The non-natural analogs of SAM and/or SeAM have the general formula: where X is S or Se, and R1 is an alkyl group.
