29475-64-7

Basic information

• Product Name: N-METHYL-D-ALANINE
• Synonyms: N-METHYL-D-ALANINE;N-Me-D-Ala-OH;N-Methyl-D-alanine hydrochloride≥ 98% (HPLC)
• CAS NO: 29475-64-7
• Molecular Formula: C₄H₉NO₂
• Molecular Weight: 103.11976
• EINECS: 1312995-182-4
• Product Categories: amino acid;Amino acids
• Mol File: 29475-64-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 190.1 °C at 760 mmHg
• Flash Point: 68.8 °C
• Appearance: White/Powder
• Density: 1.048 g/cm³
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 2.32±0.10(Predicted)
• CAS DataBase Reference: N-METHYL-D-ALANINE(CAS DataBase Reference)
• NIST Chemistry Reference: N-METHYL-D-ALANINE(29475-64-7)
• EPA Substance Registry System: N-METHYL-D-ALANINE(29475-64-7)

Safety Data

• Hazardous Substances Data: 29475-64-7(Hazardous Substances Data)

Usage

Chemical Properties

White to off white powder

Upstream product

• 70836-98-5 (S)-2-(p-toluenesulphonyloxy)propionic acid 
• 74-89-5 methylamine 
• 1400276-81-4 (4aS,10aR,13S,19aR,21aS,26bR,27aS,30R)-24-chloro-2,3,4,4a,8,9,10,10a,12,13,17,18,19,19a,22,26b,27,27a,29,30-icosahydro-25,26b-dihydroxy-12,13-dimethyl-30-(propan-2-yl)-7H,21aH-tripyridazino[1’’,6’’:10’,11’;1’’’,6’’’:16’,17’;1’’’’,6’’’’:7’,8’] [1,4,7,10,13,16]hexaazacyclooctadecino[1’,2’:1,5]pyrrolo[2,3-b]indole-5,11,14,20,28,31(1H,16H)-hexone 
• 1400276-80-3 (4aS,10aR,13S,19aR,21aS,26bR,27aS,30S)-24-chloro-2,3,4,4a,8,9,10,10a,12,13,17,18,19,19a,22,26b,27,27a,29,30-icosahydro-26b-hydroxy-12,13-dimethyl-30-(2-methylpropyl)-7H,21aH-tripyridazino[1’’,6’’:10’,11’;1’’’,6’’’:16’,17’;1’’’’,6’’’’:7’,8’] [1,4,7,10,13,16]hexaazacyclooctadecino[1’,2’:1,5]pyrrolo[2,3-b]indole-5,11,14,20,28,31(1H,16H)hexone 
• 89384-50-9 (+)-N-methyl-N-benzyl-(R)-Ala 
• 32644-15-8 (S)-2-bromopropanoic acid 

Downstream Products

• 194736-82-8 L-FDAA-D-N-methylalanine 
• 847925-82-0 C₁₆H₂₃N₅O₇ 
• 13734-31-1 N-tert-butoxycarbonyl-N-methyl-(R)-alanine 
• 1428848-52-5 (R)-2-(N-methylphenylsulfonamido)-propanoic acid 
• 1121527-27-2 (2R)-2-(N,9-dimethyl-3-(tetrahydro-2H-pyran-4-yl)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamido)propanoic acid 
• 133499-53-3 Boc-Ala-Me-D-Ala-OCH₂Ph 

Relevant articles and documents

Preparation method of N-methylamino acid with optical configurations

The invention belongs to the field of medicine synthesis, relates to a preparation method of N-methylamino acid with optical configurations and in particular relates to a preparation method of N-methylamino acid with an R configuration and an S configuration. The preparation method is shown in the description. According to the preparation method provided by the invention, the configurations of reactants are transformed to obtain the N-methylamino acid with corresponding opposite configurations, and the preparation method is suitable for commercial scale production.

Foxo3a Inhibitors of Microbial Origin, JBIR-141 and JBIR-142

JBIR-141 (1) and JBIR-142 (2) were discovered as potent Foxo3a inhibitors that consist of three quite unique substructures, a 1-((dimethylamino)ethyl)-5-methyl-4,5-dihydrooxazole-4-carboxylic acid that is originated from Ala-Thr amino acid residues, a 3-acetoxy-4-amino-7-(hydroxy(nitroso)amino)-2,2-dimethylheptanoic acid, and an α-acyl tetramic acid fused with a 2-methylpropan-1-ol moiety. Their structures involving absolute configurations were determined by spectroscopic data, chemical degradation, anisotropy methods, and LC-MS analyses of diastereomeric derivatives. Compounds 1 and 2 exhibited specific inhibition against Foxo3a transcriptional activity with IC50 values of 23.1 and 166.2 nM, respectively.

Cyclodepsipeptides, sesquiterpenoids, and other cytotoxic metabolites from the filamentous fungus Trichothecium sp. (MSX 51320)

Two new cyclodepsipeptides (1 and 2), two new sesquiterpenoids (3 and 4), and the known compounds guangomide A (5), roseotoxin S, and three simple trichothecenes were isolated from the cytotoxic organic extract of a terrestrial filamentous fungus, Trichothecium sp. The structures were determined using NMR spectroscopy and mass spectrometry. Absolute configurations of the cyclodepsipeptides were established by employing chiral HPLC, while the relative configurations of 3 and 4 were determined via NOESY data. The isolation of guangomide A was of particular interest, since it was reported previously from a marine-derived fungus.