29478-57-7

Upstream product

• 100-52-7 benzaldehyde 
• 19362-96-0 2-(1-hydroxybenzyl)acrylonitrile 
• 100-46-9 benzylamine 
• 18151-58-1 2-trimethylsilylpropionitrile 
• 107-12-0 propiononitrile 
• 19481-82-4 2-bromopropionitrile 

Downstream Products

• 29478-51-1 (2RS,3SR)-3-hydroxy-2-methyl-3-phenylpropionamide 
• 220594-77-4 3-amino-2-methyl-1-phenylpropanol 
• 1342253-37-5 1-hydroxy-2-methyl-1-phenylhex-5-en-3-one 
• 790221-69-1 syn,syn-3,6-dimethyl-2-phenyl-tetrahydropyran-4-one 
• 790221-69-1 anti,anti-3,6-dimethyl-2-phenyl-tetrahydropyran-4-one 
• 220594-78-5 E-β-methyl-β-(N-trifluoroacetyl-aminomethyl)styrene 
• 220594-79-6 Z-β-methyl-β-(N-trifluoroacetyl-aminomethyl)styrene 
• 97294-57-0 <(Z)-2-methyl-3-phenyl-2-propenyl>amine 
• 97294-57-0 (E)-2-methyl-3-phenylprop-2-en-1-amine 

Relevant academic research and scientific papers

A robust nickel catalyst for cyanomethylation of aldehydes: Activation of acetonitrile under base-free conditions

Nick of time: The nickel cyanomethyl complex 1 catalyzes the room temperature coupling of aldehydes with acetonitrile under base-free conditions. The catalytic system is long-lived and remarkably efficient with high turnover numbers (TONs) and turnover fr

One-pot nitrile aldolization/hydration operation giving β-hydroxy carboxamides

Rhodium to the rescue: The formal aldol products of carboxamides (CONH 2) were obtained by using a RhI(OR) (R=H, Me) catalyst under essentially neutral pH and ambient conditions. This novel aldol strategy is based on the catalytic al

Reaction of the electrogenerated cyanomethyl anion with carbonyl compounds: A clean and safe synthesis of β-hydroxynitriles

The electrogenerated cyanomethyl anion reacts with carbonyl compounds to yield the corresponding β-hydroxymtriles in moderate to high yields. The reported methodology is very clean and safe, avoiding the use of any classical base or catalyst.

RhI-catalyzed aldol-type reaction of organonitriles under mild conditions

An aldol-type reaction of organonitriles with aldehydes was catalyzed by a RhI(OR) species under ambient conditions, and the reaction displayed a broad substrate scope with respect to both organonitrile and aldehyde components. The Royal Societ

Lewis base-catalyzed cyanomethylation of carbonyl compounds with (trimethylsilyl)acetonitrile

Catalytic cyanomethylation of various carbonyl compounds with (trimethylsilyl)acetonitrile (TMSCH2CN) in the presence of Lewis bases such as cesium or lithium acetate proceeded smoothly to afford the corresponding cyanomethylated adducts in good yields. Copyright

Addition of α-halo-substituted carbonitriles to and aldehydesketones in the presence of iron pentacarbonyl

Halo-substituted carbonitriles in the presence of iron pentacarbonyl react with aldehydes and ketones by Reformatsky reaction type. In contract to halo-substituted esters the nitriles are considerably more reactive toward ketones than aldehydes. At the same time the structure and yield of products obtained from both nitriles and esters are strongly and similarly affected by the character of the para-substituents in the benzaldehyde.

An efficient stereoselective synthesis of (E)- and (Z)-trisubstituted alkenes from unactivated Baylis-Hillman adducts using NaBH4/CuCl 2·2H2O

A convenient and facile stereoselective synthesis of (E)- and (Z)-trisubstituted alkenes has been achieved by treatment of unactivated Baylis-Hillman adducts with NaBH4 in the presence of CuCl 2·2H2O at room temperature for 15 min.

Direct catalytic aldol-type reactions using RCH2CN

(Matrix presented) A copper fluoride-catalyzed cyanomethylation that can be applied to a wide range of ketones and aldehydes was developed using TMSCH2CN as a nucleophile. The reaction was extended to a conceptually more advanced copper alkoxid

Syntheses of amino nitrones. Potential intramolecular traps for radical intermediates in monoamine oxidase-catalyzed reactions

Monoamine oxidase (MAO) is a flavin-dependent enzyme that catalyzes the oxidative deamination of a variety of amine neurotransmitters and toxic amines. Although there have been several studies that support the intermediacy of an amine radical cation and a