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Chloroacetic acid 2-(2-chloroacetoxy)phenyl ester is a chemical compound with the molecular formula C8H6Cl2O3. It is an ester derivative of chloroacetic acid, where the hydroxyl group of the phenol is replaced by a chloroacetoxy group. chloroacetic acid 2-(2-chloroacetoxy)phenyl ester is characterized by its potential reactivity due to the presence of the chloroacetoxy group, which can undergo nucleophilic substitution reactions. It is used in organic synthesis, particularly in the preparation of various pharmaceuticals and agrochemicals, where its reactivity can be exploited to form new carbon-carbon or carbon-heteroatom bonds. The compound is typically handled with care due to its potential toxicity and reactivity, and it is an important intermediate in the synthesis of certain chemical products.

2948-15-4

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2948-15-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 2948-15-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,9,4 and 8 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 2948-15:
(6*2)+(5*9)+(4*4)+(3*8)+(2*1)+(1*5)=104
104 % 10 = 4
So 2948-15-4 is a valid CAS Registry Number.

2948-15-4Downstream Products

2948-15-4Relevant academic research and scientific papers

Synthesis and biological evaluation of phenstatin metabolites

Ghinet, Alina,Rigo, Beno?t,Hénichart, Jean-Pierre,Le Broc-Ryckewaert, Delphine,Pommery, Jean,Pommery, Nicole,Thuru, Xavier,Quesnel, Bruno,Gautret, Philippe

supporting information; experimental part, p. 6042 - 6054 (2011/11/29)

Previous investigations on the incubation of phenstatin with rat and human microsomal fractions revealed the formation of nine main metabolites. The structures of eight of these metabolites have been now confirmed by synthesis and their biological properties have been reported. Eaton's reagent was utilized as a convenient condensing agent, allowing, among others, a simple multigram scale preparation of phenstatin. Synthesized metabolites and related compounds were evaluated for their antiproliferative activity in the NCI-60 cancer cell line panel, and for their effect on microtubule assembly. Metabolite 23 (2′-methoxyphenstatin) exhibited the most potent in vitro cytotoxic activity: inhibition of the growth of K-562, NCI-H322M, NCI-H522, KM12, M14, MDA-MB-435, NCI/ADR-RES, and HS 578T cell lines with GI50 values 50 = 3.2 μM vs 15.0 μM) and induced G2/M arrest in murine leukemia DA1-3b cells. The identification of this active metabolite led to the design and synthesis of analogs with potent in vitro cytotoxicity and inhibition of microtubule assembly.

Microwave-assisted synthesis of aromatic bis-esters in liquid phase

Zbancioc, Gheorghita N.,Zbancioc, Ana Maria V.,Mangalagiu, Ionel I.

experimental part, p. 117 - 122 (2011/08/05)

A fast, general, environmentally friendly, and facile method for preparation of phenyl bis-esters under microwave irradiation in liquid phase is presented. Selective reaction pathways in order to get phenyl bis-esters only or phenyl monoesters only have b

Environmentally friendly methods for syntheses of new aromatic bisesters

Zbancioc, Gheorghita N.,Zbancioc, Ana Maria V.,Mangalagiu, Ionel I.

experimental part, p. 2201 - 2208 (2010/09/30)

Two environmentally friendly methods, one in liquid and the other in solid phase, for preparation of phenyl bisesters (bearing alkylating groups) under microwave (MW) irradiation are presented. The MW remarkably enhanced the rate of acceleration for ester

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